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Validation of Image Qualities of a Novel Four-Mice Bed PET System as an Oncological and Neurological Analysis Tool
- Source :
- Journal of Imaging, Vol 7, Iss 43, p 43 (2021), Journal of Imaging
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Background: Micro-positron emission tomography (micro-PET), a small-animal dedicated PET system, is used in biomedical studies and has the quantitative imaging capabilities of radiotracers. A single-bed system, commonly used in micro-PET, is laborious to use in large-scale studies. Here, we evaluated the image qualities of a multi-bed system. Methods: Phantom imaging studies were performed to assess the recovery coefficients (RCs), uniformity, and spill-over ratios (SORs) in water- and air-filled chambers. 18F-FDG and 18F-FPEB PET images of xenograft and normal mice from the multi-bed and single-bed systems were compared. Results: For small diameters (< 3 mm), the RC values between the two systems differed significantly. However, for large diameters (> 4 mm), there were no differences in RC values between the two systems. Uniformity and SORs of both systems were within the tolerance limit of 15%. In the oncological study, the estimation of 18F-FDG uptake in the tumor was significantly lower in the multi-bed system than that in the single-bed system. However, 18F-FDG PET in xenograft mice with tumor size > 4 mm revealed the variation between subjects within the multi-bed system group to be less than 12%. In the neurological study, SUV for the multi-bed group was 25–26% lower than that for the single-bed group; however, inter-object variations within the multi-bed system were below 7%. Conclusions: Although the multi-bed system showed lower estimation of radiotracer uptake than that of the single-bed system, the inter-subject variations were within acceptable limits. Our results indicate that the multi-bed system can be used in oncological and neurological studies.
- Subjects :
- positron emission tomography
Quantitative imaging
lcsh:Computer applications to medicine. Medical informatics
Tolerance limit
lcsh:QA75.5-76.95
Imaging phantom
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
medicine
Radiology, Nuclear Medicine and imaging
lcsh:Photography
Electrical and Electronic Engineering
Tumor size
medicine.diagnostic_test
multi-bed system
business.industry
Brief Report
neurology
lcsh:TR1-1050
Computer Graphics and Computer-Aided Design
Positron emission tomography
oncology
lcsh:R858-859.7
lcsh:Electronic computers. Computer science
Computer Vision and Pattern Recognition
Tomography
business
Nuclear medicine
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 2313433X
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of Imaging
- Accession number :
- edsair.doi.dedup.....e08fe3ce77b911ffbc3587cd148e7f4e
- Full Text :
- https://doi.org/10.3390/jimaging7030043