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Regulation of systemic tissue injury by coagulation inhibitors in B6.MRL/lpr autoimmune mice
- Source :
- Clinical immunology (Orlando, Fla.). 197
- Publication Year :
- 2018
-
Abstract
- Impaired fibrinolysis and complement activation in Systemic Lupus Erythematosus contributes to disease amplification including increased risk of thrombosis and tissue Ischemia/Reperfusion (IR) injury. Previous work has demonstrated complement is a key regulator of tissue injury. In these studies inhibitors had varying efficacies in attenuating injury at primary versus systemic sites, such as lung. In this study the role of coagulation factors in tissue injury and complement function was evaluated. Tissue Factor Pathway Inhibitor (TFPI), an extrinsic pathway inhibitor, and Anti-Thrombin III, the downstream common pathway inhibitor, were utilized in this study. TFPI was more effective in attenuated primary intestinal tissue injury. However both attenuated systemic lung injury. However, ATIII treatment resulting in enhanced degradation of C3 split products in lung tissue compared to TFPI. This work delineates the influence of specific early and late coagulation pathway components during initial tissue injury versus later distal systemic tissue injury mechanism.
- Subjects :
- 0301 basic medicine
Mice, Inbred MRL lpr
medicine.medical_treatment
Lipoproteins
Immunology
Antithrombin III
Regulator
030204 cardiovascular system & hematology
Lung injury
Antithrombins
03 medical and health sciences
Mice
0302 clinical medicine
Tissue factor pathway inhibitor
Fibrinolysis
Intestine, Small
medicine
Immunology and Allergy
Animals
Lupus Erythematosus, Systemic
Lung
business.industry
Anticoagulants
Lung Injury
medicine.disease
Thrombosis
Complement system
030104 developmental biology
medicine.anatomical_structure
Coagulation
Mesenteric Ischemia
Reperfusion Injury
Cancer research
business
Subjects
Details
- ISSN :
- 15217035
- Volume :
- 197
- Database :
- OpenAIRE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Accession number :
- edsair.doi.dedup.....e0931b605533a628f738d4370e1929a7