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Fermented pomegranate extracts protect against oxidative stress and aging of skin
- Source :
- Journal of cosmetic dermatologyREFERENCES. 21(5)
- Publication Year :
- 2021
-
Abstract
- BACKGROUND Punica granatum (pomegranate) potentially ameliorates skin inflammation and pain, including herpetic stromal keratitis. Fermentation is a biotechnological technique that may naturally induce health benefits by producing antioxidants. However, the anti-aging effect of fermented pomegranate extracts (FPE) on the skin is still unclear. AIM This investigation evaluates the effects of fermented pomegranate as a functional supplement (FPE drink, FPE-D) and a cosmetic ingredient (FPE serum, FPE-S) in vitro and in vivo. PATIENTS/METHODS The effects of FPE products for anti-oxidation, anti-tyrosinase, anti-inflammation, and anti-aging were examined. Forty subjects were randomly allocated to FPE-D or placebo drink groups (50 ml of a FPE-D /placebo drink daily for 8 weeks for each subject), and another 40 subjects were recruited to FPE-S or placebo serum groups (about 3 ml of a FPE-S /placebo serum daily and nightly/daily for 4 weeks for each subject) in a double-blind study. RESULTS The effects of FPE products on the DPPH, ABTS+ , and NO· free radical scavenging activities, their inhibiting of tyrosinase activity and their enhancement of the skin health of healthy subjects, were investigated. FPE-D improved the moisture, brightness, elasticity, and collagen density of the skin of most subjects at 8 weeks relative to the baseline without treatment (p
- Subjects :
- Aging
Antioxidant
DPPH
medicine.medical_treatment
Dermatology
Placebo
medicine.disease_cause
Antioxidants
Pomegranate
Skin Aging
chemistry.chemical_compound
In vivo
Medicine
Humans
Food science
ABTS
biology
business.industry
Plant Extracts
biology.organism_classification
Oxidative Stress
chemistry
Punica
business
Oxidative stress
Subjects
Details
- ISSN :
- 14732165
- Volume :
- 21
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of cosmetic dermatologyREFERENCES
- Accession number :
- edsair.doi.dedup.....e09bd127b4758beb4d3d2fdfbd2b90bd