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Tetherin inhibits prototypic foamy virus release
- Source :
- Virology Journal, Vol 8, Iss 1, p 198 (2011), Virology Journal
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Background Tetherin (also known as BST-2, CD317, and HM1.24) is an interferon- induced protein that blocks the release of a variety of enveloped viruses, such as retroviruses, filoviruses and herpesviruses. However, the relationship between tetherin and foamy viruses has not been clearly demonstrated. Results In this study, we found that tetherin of human, simian, bovine or canine origin inhibits the production of infectious prototypic foamy virus (PFV). The inhibition of PFV by human tetherin is counteracted by human immunodeficiency virus type 1 (HIV-1) Vpu. Furthermore, we generated human tetherin transmembrane domain deletion mutant (delTM), glycosyl phosphatidylinositol (GPI) anchor deletion mutant (delGPI), and dimerization and glycosylation deficient mutants. Compared with wild type tetherin, the delTM and delGPI mutants only moderately inhibited PFV production. In contrast, the dimerization and glycosylation deficient mutants inhibit PFV production as efficiently as the wild type tetherin. Conclusions These results demonstrate that tetherin inhibits the release and infectivity of PFV, and this inhibition is antagonized by HIV-1 Vpu. Both the transmembrane domain and the GPI anchor of tetherin are important for the inhibition of PFV, whereas the dimerization and the glycosylation of tetherin are dispensable.
- Subjects :
- Glycosylation
viruses
Human Immunodeficiency Virus Proteins
Mutant
GPI-Linked Proteins
lcsh:Infectious and parasitic diseases
chemistry.chemical_compound
Dogs
Viral envelope
Antigens, CD
Virology
Animals
Humans
Viral Regulatory and Accessory Proteins
lcsh:RC109-216
Spumavirus
Virus Release
biology
Research
Wild type
Haplorhini
biology.organism_classification
Protein Structure, Tertiary
Transmembrane domain
Infectious Diseases
chemistry
Host-Pathogen Interactions
HIV-1
Tetherin
Cattle
Protein Multimerization
Subjects
Details
- ISSN :
- 1743422X
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Virology Journal
- Accession number :
- edsair.doi.dedup.....e0a19675fb59bf89cbfe40da7fca7ca6