Back to Search
Start Over
Disturbed B cell subpopulations and increased plasma cells in myasthenia gravis patients
- Source :
- Journal of Neuroimmunology. 264:114-119
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Whether there is a general perturbation of B and plasma cell subsets in myasthenia gravis (MG) has not been investigated so far. Here we performed a detailed flow cytometric analysis of blood and if available thymic tissue in order to detect MG-specific and therapy-induced changes. We observed significant differences in the distribution of B cell subsets in MG patients, yet these were mainly attributable to medical treatment. Furthermore MG is associated with significantly increased frequencies of plasma cells that were especially activated in purely ocular disease manifestation. In contrast to thymoma, B cell subset distribution in hyperplastic thymus could be distinguished from peripheral blood, however both tissues were not significantly enriched with plasma cells. Thus B cell differentiation in general is not defective in MG, but modified by therapy and enhanced frequencies of plasma cells can be detected in MG patients.
- Subjects :
- Male
medicine.medical_specialty
Thymoma
Plasma Cells
Immunology
B-Lymphocyte Subsets
Plasma cell
Biology
medicine.disease_cause
Autoimmunity
Antigens, CD
Internal medicine
Myasthenia Gravis
medicine
Humans
Immunology and Allergy
B cell
Aged
Medical treatment
HLA-DR Antigens
Middle Aged
Flow Cytometry
medicine.disease
Peripheral blood
Myasthenia gravis
Thymic Tissue
medicine.anatomical_structure
Endocrinology
Neurology
Female
Neurology (clinical)
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 264
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....e0a3bae913158422500a8221bbd95ed8