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Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
- Source :
- Journal of Enzyme Inhibition and Medicinal Chemistry. 22:425-432
- Publication Year :
- 2007
- Publisher :
- Informa UK Limited, 2007.
-
Abstract
- Nine potential non-symmetrical xylene-bridged AChE reactivators were synthesized using modifications of currently known synthetic pathways. Their potency to reactivate AChE inhibited by the nerve agent tabun and the insecticide paraoxon together with nine symmetrical xylene-bridged compounds, was tested in vitro. Seven compounds were promising against paraoxon-inhibited AChE. Two compounds were found to be more potent against tabun-inhibited AChE than obidoxime at a concentration applicable in vivo.
- Subjects :
- Obidoxime
Obidoxime Chloride
Aché
Stereochemistry
Chemistry, Pharmaceutical
Pyridinium Compounds
Xylenes
Paraoxon
chemistry.chemical_compound
In vivo
Drug Discovery
medicine
Chemical Warfare Agents
Pesticides
Nerve agent
Tabun
Pharmacology
General Medicine
Oxime
Acetylcholinesterase
Organophosphates
language.human_language
Chemistry
Models, Chemical
chemistry
Drug Design
language
Salts
Cholinesterase Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 14756374 and 14756366
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Enzyme Inhibition and Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....e0c8754578a98138bfbc87b6e257cb0a