Cytotoxic farnesyl glycosides from Pittosporum pancheri

Authors :: Marc Litaudon
Odile Thoison
Françoise Guéritte
Véronique Eparvier
Thierry Sévenet
Hadjira Bousserouel
Institut de Chimie des Substances Naturelles (ICSN)
Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
Centre National de la Recherche Scientifique (CNRS)
Source :: Phytochemistry, Phytochemistry, Elsevier, 2007, 68 (5), pp.604-608. ⟨10.1016/j.phytochem.2006.11.008⟩, Phytochemistry, 2007, 68 (5), pp.604-608. ⟨10.1016/j.phytochem.2006.11.008⟩, Pest Management Science, Pest Management Science, Wiley, 2011, 67 (11), pp.1420-1423. ⟨10.1016/j.phytochem.2006.11.008⟩
Publication Year :: 2007
Publisher :: HAL CCSD, 2007.
Abstract: International audience; Bioassay guided purification of the ethanolic extract of the bark of New Caledonian Pittosporum pancheri Brongn. and Gris (Pittosporaceae) led to the isolation and characterization of two new farnesyl monoglycosides, pancherins A and B. The structure of these compounds were determined on the basis of spectroscopic studies. The new compounds displayed a significant activity in the in vitro cytotoxic assay against KB cancer cell line, and pancherin A inhibits weakly farnesyl protein transferase.

Subjects :: Magnetic Resonance Spectroscopy
Pittosporaceae
Farnesyl Protein Transferase
Stereochemistry
Cytotoxicity
Antineoplastic Agents
Plant Science
Horticulture
Biology
01 natural sciences
Biochemistry
KB Cells
03 medical and health sciences
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Humans
[CHIM]Chemical Sciences
Bioassay
Glycosides
Rosales
Molecular Biology
Chromatography, High Pressure Liquid
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
Plant Stems
Plant Extracts
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Pancherin
Farnesyl glycoside
Glycoside
Biological activity
General Medicine
Pittosporum
Pittosporum pancheri
biology.organism_classification
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
visual_art
visual_art.visual_art_medium
Bark
Sesquiterpenes

Language :: English
ISSN :: 00319422, 1526498X, and 15264998
Database :: OpenAIRE
Journal :: Phytochemistry, Phytochemistry, Elsevier, 2007, 68 (5), pp.604-608. ⟨10.1016/j.phytochem.2006.11.008⟩, Phytochemistry, 2007, 68 (5), pp.604-608. ⟨10.1016/j.phytochem.2006.11.008⟩, Pest Management Science, Pest Management Science, Wiley, 2011, 67 (11), pp.1420-1423. ⟨10.1016/j.phytochem.2006.11.008⟩
Accession number :: edsair.doi.dedup.....e11818e1786b21e8885df960d9d2786b
Full Text :: https://doi.org/10.1016/j.phytochem.2006.11.008⟩