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Rh(III)-catalyzed intramolecular redox-neutral or oxidative cyclization of alkynes: short, efficient synthesis of 3,4-fused indole skeletons
- Source :
- Organic letters. 16(15)
- Publication Year :
- 2014
-
Abstract
- A Rh(III)-catalyzed intramolecular redox-neutral or oxidative annulation of a tethered alkyne has been developed to efficiently construct 3,4-fused indoles via a C–H activation pathway. The advantages of this process are (1) ready availability of annulation precursors; (2) broad substrate scope; (3) complete regioselectivity; (4) simple and mild reaction conditions; and (5) no need for an external oxidant or to employ molecular oxygen as the stoichiometric terminal oxidant.
- Subjects :
- Indole test
chemistry.chemical_classification
Annulation
Indoles
Chemistry
Stereochemistry
Organic Chemistry
Substrate (chemistry)
Regioselectivity
Alkyne
Biochemistry
Redox
Combinatorial chemistry
Catalysis
Cyclization
Intramolecular force
Alkynes
Rhodium
Physical and Theoretical Chemistry
Oxidation-Reduction
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 16
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....e12f35743a9f25bb9d1a7aa67997ca33