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A nutraceutical combination reduces left ventricular mass in subjects with metabolic syndrome and left ventricular hypertrophy: A multicenter, randomized, double-blind, placebo-controlled trial
- Source :
- Clinical nutrition (Edinburgh, Scotland). 39(5)
- Publication Year :
- 2019
-
Abstract
- Increased left ventricular mass (LVM) is often present in metabolic syndrome (MS), also in the setting of well-controlled blood pressure (BP). Aim of the present study was to evaluate the efficacy of a nutraceutical combination of berberine, red yeast rice extract and policosanol (Armolipid Plus™, AP) in reducing LVM in patients with MS and left ventricular hypertrophy (LVH).In this multicenter, randomized, double-blind, placebo-controlled trial, 158 patients with MS (IDF criteria) and LVH (LVM48 g/mOne-hundred-and-forty-five patients (AP n = 74, placebo n = 71) completed the study. A significant percentage reduction in LVM was observed in AP group vs baseline (-2.7%, p 0.0001), and compared to placebo (-4.1%, p 0.0001), and remained significant after adjustment for age, sex, baseline systolic BP and BMI and their changes during the study period. The proportion of subjects showing LVM reduction was higher in AP group than in the placebo group (57% vs 28%, adjusted p = 0.007). Treatment with AP was associated with improvement of lipid profile.24-week of treatment with AP is associated with a significant reduction in LVM in subjects with MS and LVH, in addition to favourable effects on lipid profile, and could represent an effective strategy aiming at reducing the associated cardiovascular risk. The trial was registered at clinicaltrials.gov with ID NCT02295176.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Heart Ventricles
Placebo-controlled study
030209 endocrinology & metabolism
Nutraceutical combination
Critical Care and Intensive Care Medicine
Left ventricular hypertrophy
Placebo
03 medical and health sciences
0302 clinical medicine
Nutraceutical
Double-Blind Method
Echocardiography
Metabolic syndrome
Internal medicine
medicine
Humans
Policosanol
030109 nutrition & dietetics
Nutrition and Dietetics
medicine.diagnostic_test
business.industry
Middle Aged
medicine.disease
Blood pressure
Dietary Supplements
Cardiology
Female
Hypertrophy, Left Ventricular
Lipid profile
business
medicine.drug
Subjects
Details
- ISSN :
- 15321983
- Volume :
- 39
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical nutrition (Edinburgh, Scotland)
- Accession number :
- edsair.doi.dedup.....e17f06cdaf5155506c20463d22e9e9b3