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Omega-3 LCPUFA supplementation improves neonatal and maternal bone turnover: A randomized controlled trial
- Source :
- Journal of Functional Foods, Vol 46, Iss, Pp 167-174 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- The aim of this study was to evaluate for the first time the effect of omega-3 LC PUFA supplementation during pregnancy and lactation on bone metabolism in mothers and neonates. 110 pregnant women were divided in two groups: control group (400 mL/day of the control dairy drink); supplemented group (400 mL/day of the fish oil-enriched dairy drink). Plasma bone biomarkers and mineral content in erythrocyte cytosol were assessed. In mothers, DHA supplementation increased OC and OPN levels and decreased IL-6 and TNF-α levels at delivery, increasing PTH levels during lactation. In neonates, DHA supplementation increased ACTH, insulin and leptin, decreasing RANKL and IL-6 in umbilical vein; increased OPG and leptin and diminished TNF-α in umbilical artery; increased OC levels, lowered PTH and TNF-α at birth. DHA supplementation during pregnancy and lactation has beneficial effects on bone turnover in both mother and neonates, representing a non-pharmacological pathway to decrease bone loss.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Bone turnover
Bone density
medicine.medical_treatment
Medicine (miscellaneous)
030209 endocrinology & metabolism
Bone resorption
Bone remodeling
03 medical and health sciences
0302 clinical medicine
Pregnancy
Internal medicine
Lactation
medicine.artery
medicine
Term neonates
TX341-641
Docosahexaenoicacid (DHA)
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Nutrition. Foods and food supply
Insulin
Leptin
Umbilical artery
medicine.disease
Endocrinology
medicine.anatomical_structure
business
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....e1811111e9fff60e625e52f3e7f8aad7