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Association of TERT polymorphisms with chronic hepatitis B in a Chinese Han population
- Source :
- Oncotarget
- Publication Year :
- 2018
- Publisher :
- Impact Journals, LLC, 2018.
-
Abstract
- In this study, we investigated the association between the polymorphisms of telomerase reverse transcriptase (TERT) gene and the risk of chronic hepatitis B (CHB) in a Chinese Han population. Four single nucleotide polymorphisms (SNPs) in TERT (rs10069690, rs2242652, rs2853677 and rs2853676) were genotyped from 224 CHB patients and 300 healthy controls using the Sequenom Mass-ARRAY platform. We used genetic model, haplotype analyses, chi-square test, logistic regression analysis to evaluate the association between SNPs and CHB risk. The relative risk was estimated by odd ratios (ORs) and 95% confidence intervals (CIs). We found that rs10069690 was significantly associated with an increased CHB risk in the dominant model (adjusted OR = 1.70, 95% CI: 1.06–2.71, P = 0.031) and additive model (adjusted OR = 1.62, 95% CI: 1.09–2.41, P = 0.018). The haplotype “TA” (rs10069690 and rs2242652) was found to be associated with an increased risk of CHB (adjusted OR = 1.58, 95% CI: 1.05–2.38, P = 0.027). Our results suggested potential genetic contributes for TERT in CHB development in a Chinese Han population. Future functional and association studies with larger sample sizes are required to confirm these findings.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
TERT
Single-nucleotide polymorphism
Logistic regression
Gastroenterology
03 medical and health sciences
Chinese Han
0302 clinical medicine
Internal medicine
Genetic model
medicine
chronic hepatitis B
Telomerase reverse transcriptase
Genetic association
business.industry
Haplotype
single nucleotide polymorphisms (SNPs)
Confidence interval
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Relative risk
business
case-control
Research Paper
Subjects
Details
- ISSN :
- 19492553 and 10069690
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....e1a183467216e21c13596aa055ed9caa