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Effect of roflumilast on chronic obstructive pulmonary disease: a systematic review and meta-analysis
- Source :
- Irish journal of medical science. 187(3)
- Publication Year :
- 2017
-
Abstract
- Randomized controlled trials (RCTs) of roflumilast effect on chronic obstructive pulmonary disease (COPD) have been reported in the last decade. The current meta-analysis was designed to systematically review and perform meta-analysis of the RCTs of roflumilast treatment in COPD. Electronic databases including PubMed, EMBASE, Web of Science, and Cochrane clinical trials database were searched to identify RCTs of roflumilast treatment on COPD. The primary outcomes were effect of roflumilast on pre-bronchodilator FEV1, post-bronchodilator FEV1, and exacerbation rate. Secondary outcomes were effect of roflumilast on airway inflammation and adverse effect. A total of 11 RCTs were enrolled into the current analysis. Roflumilast significantly improved both pre-bronchodilator FEV1 (standardized difference in mean ± SD was 0.621 ± 0.161; 95% CI 0.306~0.936, p
- Subjects :
- Cyclopropanes
medicine.medical_specialty
Exacerbation
Aminopyridines
Rate ratio
Placebo
law.invention
03 medical and health sciences
Pulmonary Disease, Chronic Obstructive
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
medicine
Humans
030212 general & internal medicine
Adverse effect
Roflumilast
COPD
business.industry
General Medicine
medicine.disease
030228 respiratory system
Meta-analysis
Benzamides
Phosphodiesterase 4 Inhibitors
business
medicine.drug
Subjects
Details
- ISSN :
- 18634362
- Volume :
- 187
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Irish journal of medical science
- Accession number :
- edsair.doi.dedup.....e1a1a17f75801f1e8c5c7e94c5b4fdb4