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Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547
- Source :
- Marine Drugs, Vol 16, Iss 4, p 114 (2018), Marine Drugs, Marine Drugs; Volume 16; Issue 4; Pages: 114
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Chemical investigation of the marine algal-derived endophytic fungus Aspergillus alabamensis EN-547 resulted in the isolation of 4-epi-seco-shornephine A methyl ester (1) and 4-epi-seco-shornephine A carboxylic acid (2), two new secondary metabolites having a rare diketomorpholine motif, and 28-acetoxy-12β,15α,25-trihydroxyergosta-4,6,8(14),22-tetraen-3-one (3), a new highly conjugated ergostane-type steroid, together with four known metabolites (4–7). Their chemical structures were elucidated by detailed analysis of their NMR spectra, ECDs, HRESIMS, optical rotation, and X-ray crystallographic data, and by comparison with literature data as well. The antimicrobial activities of compounds 1–7 were evaluated.
- Subjects :
- Aquatic Organisms
Aspergillus alabamensis
Magnetic Resonance Spectroscopy
Ergostane
Stereochemistry
Morpholines
medicine.medical_treatment
Carboxylic acid
Pharmaceutical Science
Microbial Sensitivity Tests
Crystallography, X-Ray
01 natural sciences
Article
algal-derived endophytic fungus
Steroid
chemistry.chemical_compound
Ergosterol
Drug Discovery
medicine
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
lcsh:QH301-705.5
diketomorpholine
steroid
antimicrobial activity
chemistry.chemical_classification
Aspergillus
Bacteria
Molecular Structure
biology
010405 organic chemistry
Nuclear magnetic resonance spectroscopy
biology.organism_classification
Antimicrobial
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry
lcsh:Biology (General)
Rhodophyta
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 16
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Marine Drugs
- Accession number :
- edsair.doi.dedup.....e1c01d54bbf10a5959ed64abf6d7b590