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Survival Impact of Adjuvant Paclitaxel and Carboplatin for Early-Stage Ovarian Clear-Cell Carcinoma with Complete Surgical Staging
- Source :
- Gynecologic and Obstetric Investigation. 72:252-256
- Publication Year :
- 2011
- Publisher :
- S. Karger AG, 2011.
-
Abstract
- Objectives: The aim of this study was to estimate the survival impact of adjuvant paclitaxel and carboplatin (TC) compared to cisplatin (CDDP)-based chemotherapies for early-stage ovarian clear-cell carcinoma (CCC). Methods: Clinicopathologic information on 99 stage I–II CCC patients was obtained between 1987 and 2005. All patients underwent complete surgical staging including systemic lymphadenectomy, followed by TC or various CDDP-based regimens. In the present study, only CCC patients with no residual tumor were enrolled. Results: The median age was 53 years and ranged from 30 to 69 years. Fifty-three (53.5%) patients received TC and 46 (46.5%) patients underwent various CDDP-based chemotherapies after initial surgery. Five-year progression-free survival (PFS) rates of TC and various CDDP groups were 66.5 and 75.8%, respectively (n.s., p = 0.933). In addition, 5-year overall survival (OS) rates of TC and various CDDP groups were 82.4 and 82.3%, respectively (n.s., p = 0.583). In multivariate analyses of OS and PFS, the regimen of chemotherapywas not a significant prognostic factor (OS, p = 0.502; PFS, p = 0.977. Conclusions: In our current examination of the long-term survival of early-stage CCC patients, we did not identify a superiority of TC over various CDDP-based regimens as frontline adjuvant chemotherapy.
- Subjects :
- Adult
inorganic chemicals
Oncology
medicine.medical_specialty
Paclitaxel
medicine.medical_treatment
Carboplatin
chemistry.chemical_compound
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Stage (cooking)
neoplasms
Survival rate
Aged
Neoplasm Staging
Retrospective Studies
Ovarian Neoplasms
Cisplatin
business.industry
Obstetrics and Gynecology
Retrospective cohort study
Middle Aged
Prognosis
female genital diseases and pregnancy complications
Survival Rate
Reproductive Medicine
chemistry
Chemotherapy, Adjuvant
Clear cell carcinoma
Female
business
Adjuvant
Adenocarcinoma, Clear Cell
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 1423002X and 03787346
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Gynecologic and Obstetric Investigation
- Accession number :
- edsair.doi.dedup.....e1ce65023c7b3f09c3b868c43ebca62c