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Metabolic Profiles in Obese Children and Adolescents with Insulin Resistance
- Source :
- Open Access Macedonian Journal of Medical Sciences; Vol 6, No 3 (2018): Mar 15 (OAMJMS); 511-518, Open Access Macedonian Journal of Medical Sciences, Vol 6, Iss 3, Pp 511-518 (2018), Open Access Macedonian Journal of Medical Sciences, Open Access Macedonian Journal of Medical Sciences; Vol 6 No 3 (2018): Mar 15 (OAMJMS); 511-518
- Publication Year :
- 2018
- Publisher :
- ID Design 2012/DOOEL Skopje, Republic of Macedonia, 2018.
-
Abstract
- BACKGROUND: In the past several decades, the increasing frequency of overweight and obese children and adolescents in the world has become a public health problem. It has contributed significantly to the already high tide of diabetes, cardiovascular and cerebrovascular diseases.AIM: To investigate the frequency of insulin resistance and to evaluate the metabolic profile of insulin resistant and non-insulin resistant obese children and adolescents.SUBJECTS AND METHODS: The study included 96 (45 boys, 51 girls) obese children and adolescents aged 4-17 years old (10.50 ± 2.87 years). Only participants with Body Mass Index ≥ 95 percentile were included. We analysed sera for fasting insulin levels (FI), fasting serum triglycerides (TG), total serum cholesterol (TC), fasting plasma glucose (FPG) and plasma glucose 2 hours after the performance of the oral glucose tolerance test (2-h G). Homeostatic model assessment for insulin resistance (HOMA-IR) index was calculated as fasting insulin concentration (microunits per millilitre) x fasting glucose concentration (millimolar)/22.5. The value of HOMA-IR above 3.16 was used as a cut-off value for both genders.RESULTS: Insulin resistance was determined in 58.33% of study participants. Insulin resistant participants had significantly higher level of 2-h G (p = 0.02), FI level (p = 0.000) as well as TG levels (p = 0.01), compared to non-insulin resistant group. Strikingly, 70.73% of the pubertal adolescents were insulin resistant in comparison to 49.09% of the preadolescents (p = 0.03). Significantly higher percentage of insulin-resistant participants were girls (p = 0.009). Moreover, a higher percentage of the girls (70.59%) than boys (44.44%) had HOMA-IR above 3.16 and had elevated FI levels (70.59% vs 48.89%). The difference in the frequency of insulin resistance among obese versus severely obese children and adolescents was not significant (p = 0.73, p > 0.05). Our study results also showed positive, but weak, correlation of HOMA-IR with age, FPG, TG and BMI of the participants (p < 0.05).CONCLUSION: Higher percentage of insulin-resistant participants was of female gender and was adolescents. In general, insulin resistant obese children and adolescents tend to have a worse metabolic profile in comparison to individuals without insulin resistance. It is of note that the highest insulin resistance was also linked with the highest concentrations of triglycerides.
- Subjects :
- medicine.medical_specialty
Percentile
lcsh:Medicine
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Overweight
Fasting insulin
Childhood obesity
Pediatric endocrinology
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Obesity in adolescents
Internal medicine
Diabetes mellitus
Homeostatic model assessment of insulin resistance
Medicine
Metabolic parameters
business.industry
lcsh:R
General Medicine
Clinical Science
medicine.disease
Endocrinology
Homeostatic model assessment
medicine.symptom
business
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 18579655
- Database :
- OpenAIRE
- Journal :
- Open Access Macedonian Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....e1d73f21ee0c997371752d330a71cf5c