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Search for the sex-determining switch in monotremes: mapping WT1, SF1, LHX1, LHX2, FGF9, WNT4, RSPO1 and GATA4 in platypus
- Source :
- Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 15(6)
- Publication Year :
- 2007
-
Abstract
- The duck-billed platypus has five pairs of sex chromosomes, but there is no information about the primary sex-determining switch in this species. As there is no apparent SRY orthologue in platypus, another gene must acquire the function of a key regulator of the gonadal male or female fate. SOX9 was ruled out from being this key regulator as it maps to an autosome in platypus. To check whether other genes in mammalian gonadogenesis could be the primary switch in monotremes, we have mapped a number of candidates in platypus. We report here the autosomal location of WT1, SF1, LHX1, LHX9, FGF9, WNT4 and RSPO1 in platypus, thus excluding these from being key regulators of sex determination in this species. We found that GATA4 maps to sex chromosomes Y1 and X2; however, it lies in the pairing region shown by chromosome painting to be homologous, so is unlikely to be either male-specific or differentially dosed in male and female.
- Subjects :
- Fibroblast Growth Factor 9
Male
Chromosomes, Artificial, Bacterial
Steroidogenic Factor 1
Wnt4 Protein
biology.animal
parasitic diseases
WNT4
Genetics
Homologous chromosome
Animals
Humans
RSPO1
Platypus
Gene
Metaphase
Homeodomain Proteins
Autosome
biology
Models, Genetic
Sex Determination Processes
Human genetics
GATA4 Transcription Factor
Wnt Proteins
Testis determining factor
Gene Expression Regulation
Female
Thrombospondins
Subjects
Details
- ISSN :
- 09673849
- Volume :
- 15
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
- Accession number :
- edsair.doi.dedup.....e1de3244e1cfb35286adc93c3fdc0a25