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Cellular proliferation/cytotoxicity and antimicrobial potentials of green synthesized silver nanoparticles (AgNPs) using Juniperus procera
- Source :
- Saudi Journal of Biological Sciences, Vol 26, Iss 7, Pp 1689-1694 (2019), Saudi Journal of Biological Sciences
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Graphical abstract<br />Juniperus spp. are used as medicinal plants in many countries like Bosnia, Lebanon, and Turkey. In folk medicines, these plants have been used for treating skin and respiratory tract diseases, urinary problems, rheumatism and gall bladder stones. The objectives of this work were to synthesize silver nanoparticles (AgNPs) using a coniferous tree, Juniperus procera leaf extract and testing the synthesized AgNPs for its antimicrobial potentials, hemolytic activity, toxicity and the proliferative effects against normal and activated rat splenic cells. Leaf extract was prepared using acetone and ethanol as solvents. AgNPs were prepared using the acetone extract. AgNPs were validated using UV–Vis spectroscopy and scanning electron microscopy (SEM). Functional groups in the extract were identified using Fourier Transform Infrared (FT-IR) spectroscopy. SEM images of AgNPs showed spherical and cubic shapes with a uniform size distribution with an average size of 30–90 nm. FT-IR spectroscopy showed the presence of many functional groups in the plant extract. AgNPs showed promising antimicrobial activity against tested bacteria and fungus. AgNPs also expressed a stimulating activity towards the rat splenic cells in a dose dependent manner. Acetone as solvent was safer on cells than ethanol. Green synthesized AgNPs using J. procera might be used as a broad-spectrum therapeutic agent against microorganisms and as an immunostimulant agent.
- Subjects :
- 0106 biological sciences
0301 basic medicine
Juniperus procera
Antifungal
01 natural sciences
Silver nanoparticle
Article
03 medical and health sciences
chemistry.chemical_compound
Acetone
Splenic cells proliferation
Medicinal plants
Cytotoxicity
lcsh:QH301-705.5
ComputingMethodologies_COMPUTERGRAPHICS
biology
Chemistry
biology.organism_classification
Antimicrobial
Solvent
AgNPs
Antibacterial
Plant extract
030104 developmental biology
lcsh:Biology (General)
General Agricultural and Biological Sciences
Bacteria
010606 plant biology & botany
Nuclear chemistry
Subjects
Details
- Language :
- English
- Volume :
- 26
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Saudi Journal of Biological Sciences
- Accession number :
- edsair.doi.dedup.....e208a2b8fef05f7b73e85db7e61d8627