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Profiling non-tuberculous mycobacteria in an Asian setting: characteristics and clinical outcomes of hospitalized patients in Singapore
- Source :
- BMC Pulmonary Medicine, BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-7 (2018)
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Background Non-tuberculous mycobacteria (NTM) infection is an increasing problem worldwide. The epidemiology of NTM in most Asian countries is unknown. This study investigated the epidemiology, and clinical profile of inpatients in whom NTM was isolated from various anatomical sites in a Singaporean population attending a major tertiary referral centre. Methods Demographic profile, clinical data, and characteristics of patients hospitalized with NTM isolates at a major tertiary hospital over two-year period were prospectively assessed (2011–2012). Data collected included patient demographics, ethnicity, smoking status, co-morbidities, NTM species, intensive care unit (ICU) treatment, and mortality. Results A total of 485 patients (62.1% male) with 560 hospital admissions were analysed. The median patient age was 70 years. Thirteen different NTM species were isolated from this cohort. Mycobacterium abscessus (M. abscessus) (38.4%) was most frequently isolated followed by Mycobacterium fortuitum (M. fortuitum) (16.6%), Mycobacterium avium complex (MAC) (16.3%), Mycobacterium kansasii (M. kansasii) (15.4%), and Mycobacterium gordonae (M. gordonae) (6.8%). Most (91%) NTM was isolated from the respiratory tract. The three most common non-pulmonary sites were; blood (2.7%), skin wounds and abscesses (2.1%), and gastric aspirates (1.1%). A third (34.4%) of the study population had prior pulmonary tuberculosis (PTB). There was a significant association between isolated NTM species, and patient age (p=0.0002). Eleven (2.2%) patients received intensive care unit (ICU) treatment during the study period and all cause mortality within 1 year of the study was 16.9% (n=82). Of these, 72 (87.8%) patients died of pulmonary causes. Conclusions The profile of NTM species in Singapore is unique. M. abscessus is the commonest NTM isolated, with a higher prevalence in males, and in the elderly. High NTM prevalence is associated with high rates of prior PTB in our cohort. Published version
- Subjects :
- Male
0301 basic medicine
Epidemiology
Mycobacterium abscessus
law.invention
0302 clinical medicine
law
Prospective Studies
Aged, 80 and over
Singapore
education.field_of_study
biology
Nontuberculous Mycobacteria
Middle Aged
Intensive care unit
Bronchiectasis
Intensive Care Units
Female
Mycobacterium fortuitum
Non-tuberculous Mycobacteria
Research Article
Adult
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Tuberculosis
030106 microbiology
Population
Mycobacterium Infections, Nontuberculous
Mycobacterium gordonae
03 medical and health sciences
Bacterial Proteins
Internal medicine
Non-tuberculous mycobacteria
medicine
Humans
education
Tuberculosis, Pulmonary
Aged
lcsh:RC705-779
Mycobacterium kansasii
business.industry
lcsh:Diseases of the respiratory system
bacterial infections and mycoses
biology.organism_classification
medicine.disease
030228 respiratory system
business
Subjects
Details
- ISSN :
- 14712466
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- BMC Pulmonary Medicine
- Accession number :
- edsair.doi.dedup.....e20dcbbe3b3d0627a74675498c4f02a5