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Progression of pulmonary artery dilatation in patients with pulmonary hypertension coexisting with a pulmonary artery aneurysm
- Source :
- Journal of cardiology. 71(5)
- Publication Year :
- 2017
-
Abstract
- Background Pulmonary artery (PA) dilatation is usually observed in patients with pulmonary hypertension (PH), but a PA aneurysm (PA diameter > 40 mm) is rare. The difference between characteristics of patients with and those without progression of PA diameter remains poorly understood. We assessed the changes in PA diameter in patients with PH coexisting with and without a PA aneurysm. Methods We investigated the changes in PA diameter by multi-detector computed tomography performed twice with an interval of more than one year in 44 patients with PH. Seventeen patients had a PA aneurysm and 27 patients did not have a PA aneurysm at baseline. Results The median follow-up period was 3.6 years. All patients received medical or invasive treatment for PH. At baseline, main PA diameters were 52 ± 15 mm in patients with a PA aneurysm and 33 ± 3 mm in patients without a PA aneurysm. Mean PA pressure was higher in patients with a PA aneurysm than in those without a PA aneurysm (61 ± 15 mmHg vs. 51 ± 16 mmHg, p = 0.04). At follow-up, mean PA pressure significantly decreased in both patients with a PA aneurysm (44 ± 11 mmHg) and patients without a PA aneurysm (41 ± 18 mmHg). Main PA diameter significantly increased in patients with a PA aneurysm (65 ± 28 mm, change ratio: 23.3%), while it did not increase in patients without a PA aneurysm (32 ± 3 mm, change ratio: −3.1%). Conclusions PA dilatation progressed in patients with a PA aneurysm despite treatment of PH. The progression of PA dilatation is independent of reduction of PA pressure by PH treatment.
- Subjects :
- Adult
Heart Defects, Congenital
Male
medicine.medical_specialty
Adolescent
Hypertension, Pulmonary
Computed tomography
030204 cardiovascular system & hematology
Pulmonary Artery
03 medical and health sciences
Young Adult
0302 clinical medicine
Aneurysm
Predictive Value of Tests
Risk Factors
medicine.artery
Internal medicine
medicine
Humans
In patient
cardiovascular diseases
Pulmonary artery aneurysm
medicine.diagnostic_test
business.industry
Pulmonary artery dilatation
Middle Aged
medicine.disease
Pulmonary hypertension
Dilatation
Treatment Outcome
030228 respiratory system
Predictive value of tests
Pulmonary artery
cardiovascular system
Cardiology
Disease Progression
Female
Cardiology and Cardiovascular Medicine
business
Tomography, X-Ray Computed
Dilatation, Pathologic
Follow-Up Studies
Subjects
Details
- ISSN :
- 18764738
- Volume :
- 71
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of cardiology
- Accession number :
- edsair.doi.dedup.....e20e3460cfbb0efcd1bc2a4b9bdaf05f