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Genomewide screen for pulmonary function in 200 families ascertained for asthma
- Source :
- American Journal of Respiratory and Critical Care Medicine, 172(4), 446-452. AMER THORACIC SOC
- Publication Year :
- 2005
-
Abstract
- Changes in pulmonary function are important in determining asthma outcome. Genetic factors may influence airway obstruction in asthma. We performed a genomewide screen in 200 families of probands objectively diagnosed with asthma in the 1960s to identify chromosomal regions related to changes in pre- and postbronchodilator lung function (FEV1, VC, and FEV1%VC) and assess influences of early-life smoke exposure. Smoking (pack-years), age, sex, and height were covariates in variance component analyses. Significant evidence for linkage of pre- and postbronchodilator FEV1%VC was obtained for chromosome 2q32 (LOD, 4.9, increasing to 6.03 with additional fine-mapping markers, and 3.2, respectively). Linkage existed for chromosome 5q for pre- and postbronchodilator VC (likelihood of disease [LOD], 1.8 and 2.6, respectively). Results for pre- and postbronchodilator FEV1 were less significant (LOD, 1.5 and 1.6, chromosomes 11 p and 10q, respectively). Results were not affected by passive smoke exposure. There is significant evidence for linkage of FEV1%VC to chromosome 2q32 in families of probands with asthma, 35 cM proximal from linkage previously observed in families of probands with early-onset chronic obstructive pulmonary disease. Thus, there may be multiple genes on chromosome 2q that are important in determining presence and degree of airflow limitation in families ascertained for obstructive airway disease.
- Subjects :
- Male
Proband
Vital Capacity
Critical Care and Intensive Care Medicine
DISEASE
Pulmonary function testing
ENVIRONMENTAL TOBACCO-SMOKE
Forced Expiratory Volume
SPIROMETRIC PHENOTYPES
MATERNAL SMOKING
Child
medicine.diagnostic_test
Smoking
Respiratory disease
Middle Aged
Respiratory Function Tests
LUNG-FUNCTION
RESPIRATORY SYMPTOMS
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 5
Female
linkage
Adult
Pulmonary and Respiratory Medicine
medicine.medical_specialty
GENES
Genotype
IN-UTERO
lung
Genetic linkage
Internal medicine
Intensive care
medicine
Humans
Genetic Testing
Asthma
Genetic testing
function
LINKAGE ANALYSIS
business.industry
Airway obstruction
asthma
medicine.disease
A. Asthma and Allergy
respiratory tract diseases
Immunology
Tobacco Smoke Pollution
Lod Score
business
FOLLOW-UP
Subjects
Details
- Language :
- English
- ISSN :
- 1073449X
- Database :
- OpenAIRE
- Journal :
- American Journal of Respiratory and Critical Care Medicine, 172(4), 446-452. AMER THORACIC SOC
- Accession number :
- edsair.doi.dedup.....e21c3d95234bf53c72f8ab757a5ad593