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Effects of hypolipidemic and hypoglycemic agents on atherogenic small, dense LDL in Type 2 diabetes
Effects of hypolipidemic and hypoglycemic agents on atherogenic small, dense LDL in Type 2 diabetes
- Source :
- Clinical Lipidology. 6:539-547
- Publication Year :
- 2011
- Publisher :
- Informa UK Limited, 2011.
-
Abstract
- Type 2 diabetes is associated with a cluster of inter-related plasma lipid and lipoprotein abnormalities, including reduced HDL-C, a predominance of small, dense LDL and elevated triglycerides. These abnormalities occur even in prediabetes, before blood sugars rise sufficiently in order to confirm a diagnosis of diabetes, and this transition phase incurs important cardiovascular risk. This is the rationale for paying attention to dyslipidemia through the use of the hypolipidemic, rather than hypoglycemic drugs only. A literature search (by Medline and Scopus) was performed. The authors also manually reviewed the references of selected articles for any pertinent material. Beyond the ‘quantity’ of LDL, several lipid-lowering agents and particularly statins, are only in part beneficial on the ‘quality’ of LDL, so that their net effect on small, dense LDL is moderate. Among hypoglycemic agents, insulin and metformin have shown a limited role on small, dense LDL, while pioglitazone is more beneficial. The effi...
- Subjects :
- medicine.medical_specialty
business.industry
Endocrinology, Diabetes and Metabolism
Insulin
medicine.medical_treatment
Type 2 diabetes
medicine.disease
Metformin
diabetes, LDL size, prevention, small, dense LDL, therapy
Endocrinology
Internal medicine
Diabetes mellitus
medicine
lipids (amino acids, peptides, and proteins)
Prediabetes
Cardiology and Cardiovascular Medicine
business
Pioglitazone
Dyslipidemia
medicine.drug
Lipoprotein
Subjects
Details
- ISSN :
- 17584302 and 17584299
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Clinical Lipidology
- Accession number :
- edsair.doi.dedup.....e2238ae640118c6b2e4c382d6023da4d
- Full Text :
- https://doi.org/10.2217/clp.11.46