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Association between two polymorphisms in the HLA-G gene and angiographic coronary artery disease
- Source :
- Molecular medicine reports. 5(5)
- Publication Year :
- 2011
-
Abstract
- Atherosclerosis and related complications still represent the major cause of morbidity and mortality in industrialized countries. Therefore, it is particularly important to investigate the molecules involved in cardiac inflammation. Evidence exists showing that the human leukocyte antigen‑G (HLA-G) gene tissue expression and related protein physiological significance is influenced by two polymorphisms, rs16375 and rs1632933. In this study, allelic, genotypic and haplotypic frequencies of a 14-bp insertion/deletion (Ins/Del) (rs16375) and of rs1632933 polymorphisms of the HLA-G gene were investigated in 664 patients with coronary artery disease (CAD) and 345 matched controls by polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis and real-time PCR. The frequency of the Ins/Ins genotype was significantly higher in patients with CAD compared to the controls (P=0.018). After analysis of confounding variables, the results showed that the homozygous Ins/Ins was significantly and independently associated with the presence of angiographic CAD (odds ratio 2.09, 95% confidence interval 1.10-4.02, P=0.03). Our data demonstrate a new risk factor for this multifactorial inflammatory disease.
- Subjects :
- Male
Cancer Research
Disease
Human leukocyte antigen
Coronary Artery Disease
Biology
Coronary Angiography
Biochemistry
Polymerase Chain Reaction
Coronary artery disease
Genotype
Genetics
medicine
Humans
Allele
Molecular Biology
Aged
HLA-G Antigens
Confounding
Haplotype
Odds ratio
Middle Aged
medicine.disease
Oncology
Haplotypes
Immunology
Molecular Medicine
Female
Polymorphism, Restriction Fragment Length
Subjects
Details
- ISSN :
- 17913004
- Volume :
- 5
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Molecular medicine reports
- Accession number :
- edsair.doi.dedup.....e22be7af972a3acecb7158bcb5335cfb