Back to Search
Start Over
Combined oncolytic and vaccination activities of parvovirus H-1 in a metastatic tumor model
- Source :
- Oncology Reports.
- Publication Year :
- 2007
- Publisher :
- Spandidos Publications, 2007.
-
Abstract
- Oncolytic viruses have emerged as a novel class of potent anticancer agents offering an improvement on chemo- and radiotherapy in terms of tumor targeting and reduction of side-effects. Among these agents, autonomous parvoviruses have attracted the attention of researchers for their ability to preferentially replicate in and kill transformed cells, and to suppress tumors in the absence of adverse reactions in various animal models. We have previously shown that lethally irradiated autologous tumor cells can support parvovirus H-1PV production and serve as carriers to deliver progeny H-1PV into the vicinity of lung metastases in a rat tumor model, resulting in H-1PV infection of and multiplication in metastatic cells. It is known that irradiated autologous (neoplastic) cells can also act as a therapeutic vaccine against the original tumor. Yet the ability of these cells to suppress metastases in the above model was found to be much increased as a result of their H-1PV infection. This prompted us to determine whether H-1PV boosted the tumor-suppressing capacity of the autologous vaccine by increasing its immunogenic potential and/or by making it a factory of oncolytic viruses able to reach and destroy the metastases. Both effects could be dissociated in the presence of neutralising antibodies which either prevent the progeny viruses from spreading to metastatic cells, or deplete the CD8 effector cells from the immune system. This strategy revealed that the H-1PV infection of tumor cells enhanced their ability to trigger an immune response for which uninfected tumor cells could be the targets, thereby amplifying and taking over from the direct viral oncolytic activity. This dual oncolytic/vaccinal effect of H-1PV holds out promises of clinical applications to cancer therapy.
- Subjects :
- H-1 parvovirus
Cancer Research
Lung Neoplasms
Parvovirus H-1
Antibodies, Viral
Cancer Vaccines
Virus
Metastasis
Immune system
Cell Line, Tumor
medicine
Animals
Oncolytic Virotherapy
Parvoviridae
biology
Parvovirus
Rats, Inbred Strains
General Medicine
biology.organism_classification
medicine.disease
Xenograft Model Antitumor Assays
Virology
Rats
Oncolytic virus
Oncolytic Viruses
Oncology
biology.protein
Antibody
Subjects
Details
- ISSN :
- 17912431 and 1021335X
- Database :
- OpenAIRE
- Journal :
- Oncology Reports
- Accession number :
- edsair.doi.dedup.....e2391f8581fe238d424a06fdbac28967
- Full Text :
- https://doi.org/10.3892/or.17.6.1493