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Differences in nasal cellular infiltrates between allergic children and age-matched controls
- Source :
- European Respiratory Journal, 13, 797-803. European Respiratory Society, European respiratory journal, 13(4), 797-803. European Respiratory Society
- Publication Year :
- 1999
- Publisher :
- European Respiratory Society, 1999.
-
Abstract
- Little is known about the cellular infiltrates in the nasal mucosa of children. This study was set up to compare the nasal cellular infiltrates in biopsy specimens from allergic children and controls. Atopic children were distinguished from controls on the basis of symptoms of allergic rhinitis and/or asthma, total serum immunoglobulin (Ig)E, family history and specific serum IgE to food and aeroallergens. Fifteen allergic patients (median age 4.3 yrs) and 15 age-matched nonallergic control subjects were evaluated. The number of cells positive for CD1a, CD4, CD8, CD19, CD68, chymase, tryptase, IgE and major basic protein was determined in the mucosa of the inferior turbinate. A significantly higher number of IgE-positive cells and mast cells was found in the epithelia of the allergic group. In the lamina propria, higher numbers of IgE-positive cells and eosinophils were found. Langerhans' cells positive for IgE were only seen in allergic children with specific serum IgE against aeroallergens. These children also had a higher number of IgE-positive mast cells compared to controls and atopic children without specific serum IgE. These results show that the nasal cellular infiltrates of allergic children differ from nonallergic control subjects. Prior to the detection of specific serum immunoglobulin E, cellular changes can be found in the nasal mucosa of atopic children.
- Subjects :
- Pulmonary and Respiratory Medicine
Hypersensitivity, Immediate
Male
Allergy
Rhinitis, Allergic, Perennial
Biopsy
Tryptase
Mucous membrane of nose
Immunoglobulin E
Atopy
medicine
Respiratory Hypersensitivity
Humans
Mast Cells
Asthma
Lamina propria
biology
business.industry
medicine.disease
Lymphocyte Subsets
Nasal Mucosa
medicine.anatomical_structure
Case-Control Studies
Child, Preschool
Immunology
biology.protein
Female
Antibody
business
Subjects
Details
- ISSN :
- 13993003 and 09031936
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal
- Accession number :
- edsair.doi.dedup.....e25431000c4739631db6e358371ed844