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Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals
- Source :
- Nutrition & Metabolism
- Publisher :
- Springer Nature
-
Abstract
- Background A high-fat diet promotes postprandial systemic inflammation and metabolic endotoxemia. We investigated the effects of three consecutive high-fat meals on endotoxemia, inflammation, vascular function, and postprandial lipid metabolism in patients with type 1 diabetes. Methods Non-diabetic controls (n = 34) and patients with type 1 diabetes (n = 37) were given three high-caloric, fat-containing meals during one day. Blood samples were drawn at fasting (8:00) and every two hours thereafter until 18:00. Applanation tonometry was used to assess changes in the augmentation index during the investigation day. Results Three consecutive high-fat meals had only a modest effect on serum LPS-activity levels and inflammatory markers throughout the day in both groups. Of note, patients with type 1 diabetes were unable to decrease the augmentation index in response to the high-fat meals. The most profound effects of the consecutive fat loads were seen in chylomicron and HDL-metabolism. The triglyceride-rich lipoprotein remnant marker, apoB-48, was elevated in patients compared to controls both at fasting (p = 0.014) and postprandially (p = 0.035). The activities of the HDL-associated enzymes PLTP (p
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
education
Medicine (miscellaneous)
Clinical nutrition
Type 2 diabetes
Vascular dysfunction
SERUM
LIPOPROTEINS
Insulin resistance
Chylomicron remnant
INFLAMMATION
Internal medicine
medicine
ENDOTOXEMIA
HUMAN PLASMA
INCREASED RISK
Type 1 diabetes
INSULIN-RESISTANCE
TRANSFER PROTEIN
Nutrition and Dietetics
biology
business.industry
Research
Paraoxonase
medicine.disease
Obesity
3. Good health
Endocrinology
Postprandial
High-fat diet
3121 General medicine, internal medicine and other clinical medicine
biology.protein
YOUNG-PATIENTS
lipids (amino acids, peptides, and proteins)
business
ARTERIAL STIFFNESS
Subjects
Details
- Language :
- English
- ISSN :
- 17437075
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nutrition & Metabolism
- Accession number :
- edsair.doi.dedup.....e27e3a36d277d267e23f602ba90e870f
- Full Text :
- https://doi.org/10.1186/1743-7075-11-28