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Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals

Authors :
Outi Vaarala
Mariann I. Lassenius
Pirkko J. Pussinen
Juha Kirveskari
Mika Ala-Korpela
Marja-Riitta Taskinen
Per-Henrik Groop
Carol Forsblom
Markku Lehto
Pasi Soininen
Christopher L. Fogarty
Lina Peräneva
Janne K. Nieminen
Sohvi Hörkkö
Antti J. Kangas
Matti Jauhiainen
Aila J. Ahola
Ville-Petteri Mäkinen
Daniel Gordin
Clinicum
Department of Medicine
Nefrologian yksikkö
Diabetes and Obesity Research Program
Research Programs Unit
Department of Oral and Maxillofacial Diseases
Department of Diagnostics and Therapeutics
Source :
Nutrition & Metabolism
Publisher :
Springer Nature

Abstract

Background A high-fat diet promotes postprandial systemic inflammation and metabolic endotoxemia. We investigated the effects of three consecutive high-fat meals on endotoxemia, inflammation, vascular function, and postprandial lipid metabolism in patients with type 1 diabetes. Methods Non-diabetic controls (n = 34) and patients with type 1 diabetes (n = 37) were given three high-caloric, fat-containing meals during one day. Blood samples were drawn at fasting (8:00) and every two hours thereafter until 18:00. Applanation tonometry was used to assess changes in the augmentation index during the investigation day. Results Three consecutive high-fat meals had only a modest effect on serum LPS-activity levels and inflammatory markers throughout the day in both groups. Of note, patients with type 1 diabetes were unable to decrease the augmentation index in response to the high-fat meals. The most profound effects of the consecutive fat loads were seen in chylomicron and HDL-metabolism. The triglyceride-rich lipoprotein remnant marker, apoB-48, was elevated in patients compared to controls both at fasting (p = 0.014) and postprandially (p = 0.035). The activities of the HDL-associated enzymes PLTP (p

Details

Language :
English
ISSN :
17437075
Volume :
11
Issue :
1
Database :
OpenAIRE
Journal :
Nutrition & Metabolism
Accession number :
edsair.doi.dedup.....e27e3a36d277d267e23f602ba90e870f
Full Text :
https://doi.org/10.1186/1743-7075-11-28