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Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats
- Source :
- CNS Neuroscience & Therapeutics. 22:625-632
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Summary Aims Acute cerebral ischemia may lead to ischemic stroke, which is a major cause of death and disability worldwide. Hydrogen sulfide (H2S) functions importantly in mammalian systems. The present work was designed to study the effect of sodium sulfide, a donor of H2S, on acute cerebral ischemia. Methods Acute cerebral focal ischemia was produced by middle cerebral artery occlusion (MCAO) in Sprague-Dawley (SD) rats. Bilateral vertebral arteries and common carotid arteries were blocked to establish cerebral global ischemia in SD rats. Acute cerebral anoxia was produced by hypobaric anoxia in C57BL/6 mice and hypoxic anoxia in SD rats. Nimodipine and aspirin were set as positive control separately. Results Infarct size after MCAO was decreased by sodium sulfide. Sodium sulfide improved cerebral energy metabolism after cerebral global ischemia and prolonged survival time of animals with acute cerebral anoxia. In addition, increased cerebral blood flow and decreased cerebrovascular resistance, blood viscosity, and thrombogenesis were observed in animals treated with sodium sulfide. In cultured neurons, sodium sulfide increased cell viability and decreased cell apoptosis induced by oxygen-glucose deprivation. Conclusion Sodium sulfide, a H2S donor, presents protective effect on acute cerebral ischemia, and might be a promising therapeutic drug.
- Subjects :
- 0301 basic medicine
Time Factors
Hydrogen sulfide
Blood viscosity
Apoptosis
Blood Pressure
Pharmacology
Sodium sulfide
Rats, Sprague-Dawley
Mice
chemistry.chemical_compound
0302 clinical medicine
Heart Rate
Pharmacology (medical)
Stroke
Cells, Cultured
Electroencephalography
Infarction, Middle Cerebral Artery
Psychiatry and Mental health
Neuroprotective Agents
Cerebral blood flow
Cerebrovascular Circulation
Anesthesia
Acute Disease
medicine.drug
Cell Survival
Ischemia
Sulfides
03 medical and health sciences
Dogs
Fibrinolytic Agents
Physiology (medical)
medicine
Animals
cardiovascular diseases
Nimodipine
Analysis of Variance
Aspirin
Dose-Response Relationship, Drug
business.industry
Original Articles
medicine.disease
Rats
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
chemistry
Nervous System Diseases
business
030217 neurology & neurosurgery
Fibrinolytic agent
Subjects
Details
- ISSN :
- 17555930
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- CNS Neuroscience & Therapeutics
- Accession number :
- edsair.doi.dedup.....e290ab3a2f450be34931ea5acfbf92fe