Back to Search
Start Over
Seroprevalence of Kaposi's sarcoma-associated herpesvirus and risk factors in Xinjiang, China
- Source :
- Journal of medical virology. 81(8)
- Publication Year :
- 2009
-
Abstract
- Xinjiang, China is an endemic area for Kaposi’s sarcoma (KS) but the seroprevalence of Kaposi’s sarcoma-associated herpesvirus (KSHV) and risk factors remain undefined. In this study, antibodies to one KSHV latent protein (ORF73) and two KSHV lytic proteins (ORF65 and ORF-K8.1) were examined in 2,228 subjects from the general population and 37 subjects infected with HIV-1 in Xinjiang, and 560 subjects from the general population in Hubei, a low KS incidence region. The serostatus of a serum sample was defined based on positive results in any one of the three serologic assays. The seroprevalence of KSHV in the general population was higher in Xinjiang than in Hubei (19.2% vs 9.5%; odds ratios [OR], 2.28; 95% confidence interval [CI], 1.68–3.08; P < 0.001). Among the ethnic groups in Xinjiang, 68 (15.8%) Han, 182 (20.7%) Uygur, 140 (19.9%) Hazakh, 9 (33.3%) Xibo, and 29 (16.8%) Hui were KSHV-seropositive, respectively. Compared to the Han, the latter groups had an increase in the risk of KSHV of 62.2%, 63.8%, 180.1% and 30.2% (P = 0.003, 0.004, 0.018, and 0.286, respectively). Subjects aged < 20, 20–50, and > 50 had a seroprevalence of KSHV of 11.8%, 17.9% and 24.6%, respectively. Compared to subjects aged < 20, the latter groups had an increase in the risk of KSHV of 63.3% and 144.5% (P = 0.009 and < 0.001, respectively). Subjects infected with HIV-1 in Xinjiang had a seroprevalence of KSHV of 43.2%, and a 220% increase in the risk of KSHV compared to the general population (P < 0.001). Similar results were obtained when the seroprevalence of KSHV was analyzed with any single or two of the three serologic assays alone. Genotyping identified 3 unique sequences clustered in the A clade. This study indicates that Xinjiang has a high seroprevalence of KSHV. Geographic location, ethnicity, age and HIV-1 infection are risk factors. Serologic and genotyping results suggest the introduction of KSHV into Xinjiang by specific ethnic groups.
- Subjects :
- Adult
Male
China
Adolescent
Genotype
viruses
Population
Molecular Sequence Data
HIV Infections
medicine.disease_cause
Antibodies, Viral
Article
Serology
Young Adult
Blood serum
Risk Factors
Seroepidemiologic Studies
Virology
Medicine
Gammaherpesvirinae
Seroprevalence
Cluster Analysis
Humans
Kaposi's sarcoma-associated herpesvirus
Risk factor
education
Child
Kaposi's sarcoma
Aged
Aged, 80 and over
education.field_of_study
biology
Base Sequence
business.industry
Infant, Newborn
virus diseases
Infant
Herpesviridae Infections
Middle Aged
medicine.disease
biology.organism_classification
Infectious Diseases
Child, Preschool
Immunology
DNA, Viral
Herpesvirus 8, Human
Female
business
Subjects
Details
- ISSN :
- 10969071
- Volume :
- 81
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of medical virology
- Accession number :
- edsair.doi.dedup.....e2a89f3cecd5b3b2746969ba59cc588e