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HEART MUSCLE CATECHOLAMINES AND ENZYMES IN EXPERIMENTAL THYROID DISEASES
- Source :
- Japanese heart journal. 4
- Publication Year :
- 1963
-
Abstract
- (1) Heart muscle catecholamine content, pseudocholinesterase activity, and glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities were measured in rats after administration of 3, 5, 3' triiodothyronine and 1-methy 1-2-mercaptoimidazole in order to find further correlations between these and the effects of thyroid hormones. Heart muscle adrenaline content significantly decreased in hyperthyroid group compared with hypothyroid and coutrol group. The significance of this finding in explaining hypersensitivity of adrenaline in hyperthyroidism was discussed. The metabolism of catecholamines in relation to this finding was also discussed.(2) Pseudocholinesterase activity in the heart muscle significantly increased in hyperthyroid group and decreased in hypothyroid group compared with control group. Its possible significance in thyroid diseases was discussed.(3) Glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities in the heart muscle significantly decreased in hyperthyroid as well as hypothyroid group compared with control group. It is likely that muscular involvements in thyroid diseases are significant enough to cause possible liberation of these enzymes.
- Subjects :
- endocrine system
medicine.medical_specialty
endocrine system diseases
Electrons
Mitochondrion
D-Alanine Transaminase
Catecholamines
Internal medicine
medicine
Pathology
Cholinesterases
Aspartate Aminotransferases
Cholinesterase
chemistry.chemical_classification
Microscopy
Triiodothyronine
biology
business.industry
Myocardium
Research
Thyroid
Imidazoles
Alanine Transaminase
Metabolism
Thyroid Diseases
Mitochondria
Rats
Microscopy, Electron
Endocrinology
Enzyme
medicine.anatomical_structure
chemistry
biology.protein
Catecholamine
Liberation
Cardiology and Cardiovascular Medicine
business
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 00214868
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Japanese heart journal
- Accession number :
- edsair.doi.dedup.....e2bfe84ba616ed2b372f5e95dedc6777