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Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism
- Source :
- Neuron
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Sensory experience remodels neural circuits in the early postnatal brain through mechanisms that remain to be elucidated. Applying a new method of ultrastructural analysis to the retinogeniculate circuit, we find that visual experience alters the number and structure of synapses between the retina and the thalamus. These changes require the vision-dependent transcription of the receptor Fn14 in thalamic relay neurons and the induction of its ligand TWEAK in microglia. Fn14 functions to increase the number of bulbous spine-associated synapses at retinogeniculate connections likely contributing to the strengthening of the circuit that occurs in response to visual experience. However, at retinogeniculate connections nearby TWEAK-expressing microglia, TWEAK signals via Fn14 to restrict the number of bulbous spines on relay neurons, leading to the elimination of a subset of connections. Thus, TWEAK and Fn14 represent an intercellular signaling axis through which microglia shape retinogeniculate connectivity in response to sensory experience.
- Subjects :
- 0301 basic medicine
Dendritic spine
Thalamus
Mice, Transgenic
Sensory system
Biology
Article
Receptors, Tumor Necrosis Factor
Synapse
Mice
03 medical and health sciences
0302 clinical medicine
Microscopy, Electron, Transmission
medicine
Biological neural network
Animals
Visual Pathways
Postnatal brain
Neurons
Retina
Neuronal Plasticity
Microglia
General Neuroscience
Cytokine TWEAK
Mice, Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
TWEAK Receptor
Tumor Necrosis Factors
Synapses
Neuroscience
Photic Stimulation
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 08966273
- Volume :
- 108
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....e2d9cf53a6dac2fb53d05dacd16381eb
- Full Text :
- https://doi.org/10.1016/j.neuron.2020.08.002