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Association between the PNPLA3 I148M Polymorphism and Non-Alcoholic Fatty Liver Disease in the Uygur and Han Ethnic Groups of Northwestern China
- Source :
- PLoS ONE, PLoS ONE, Vol 9, Iss 10, p e108381 (2014)
- Publication Year :
- 2014
- Publisher :
- Public Library of Science, 2014.
-
Abstract
- Objective Multiple common gene variants play a role in non-alcoholic fatty liver disease (NAFLD) susceptibility. Our goal was to investigate the association between variants polymorphisms and NAFLD in the Uygur and Han from Northwestern China. Methods Eight tag single nucleotide polymorphisms (tSNPs) previously reported to be associated with NAFLD were characterized in 396 NAFLD individuals and 399 controls. The association of variants with NAFLD in the Uygur and Han was assessed using the chi-squared (χ2) test in different gene models. Unconditional logistic regression analysis was performed to obtain the odds ratios (ORs) for risk of NAFLD and their 95% confidence intervals (CI), adjusted for confounding factors. Finally, stratified analysis was used to explore the potential gene-environment interactions on the risk of NAFLD. Results In a recessive model, we found a potential association between rs738409 and NAFLD in both ethnic groups: Chinese Han (OR = 1.84, 95% CI: 1.03–3.27, p = 0.036), Uygur (OR = 2.25, 95% CI: 1.23–4.09, p = 0.006). The multiple logistic regression revealed that PNPLA3 rs738409 GG genotype may increase the risk of NAFLD by adjusting some confounding factors: Han (OR = 5.22, 95% CI: 1.94–14.04, p = 0.001), Uygur (OR = 4.29, 95% CI: 1.60–11.48, p = 0.004). Stratified analysis found that rs738409 polymorphism appeared to have interaction with sex, smoking status in Uygur, and have interaction with sex, age, BMI stage, lifestyle in Han. Conclusion Our data suggest the PNPLA3 I148M polymorphism influences susceptibility to NAFLD in the Han and Uygur of Northwestern China.
- Subjects :
- Adult
Male
medicine.medical_specialty
China
lcsh:Medicine
Single-nucleotide polymorphism
Gastroenterology and Hepatology
Biology
Logistic regression
Gastroenterology
Polymorphism, Single Nucleotide
Molecular Genetics
Non-alcoholic Fatty Liver Disease
Internal medicine
Genotype
medicine
Genetics
Medicine and Health Sciences
Odds Ratio
Humans
Genetic Predisposition to Disease
lcsh:Science
Alleles
Genetic Association Studies
Ultrasonography
Multidisciplinary
Liver Diseases
lcsh:R
Fatty liver
Confounding
Case-control study
nutritional and metabolic diseases
Biology and Life Sciences
Membrane Proteins
Odds ratio
Lipase
Middle Aged
medicine.disease
digestive system diseases
Case-Control Studies
Genetics of Disease
lcsh:Q
Female
Gene-Environment Interaction
Gene Function
Body mass index
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....e2dba8c1845e2e5ba8381b3343f5d45a