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The Application of Natural Products in Cancer Therapy by Targeting Apoptosis Pathways
- Source :
- Current Drug Metabolism. 19:739-749
- Publication Year :
- 2018
- Publisher :
- Bentham Science Publishers Ltd., 2018.
-
Abstract
- Background Apoptosis is one of the pathways of programmed cell death (PCD), which leads to pathognomic cellular changes different from cellular necrosis. It includes the death receptor pathway and the mitochondrial pathway, both of which involve many key proteins abnormally expressed in apoptosis-related diseases, such as cancer. The majority of anti-cancer natural products promote apoptosis to induce cancer cell death. In this review, we aim to survey the current knowledge on key apoptotic proteins and some representative natural products that can induce cancer cell apoptosis by regulating these proteins. Method We reviewed the recent relative literatures using a structured search of bibliographic databases, and the keywords, such as natural products, cancer therapy, and apoptosis pathway, were used for inclusion/exclusion criteria. Results One hundred and seventy-one papers are included in this review. Numerous natural products have been reported to induce cell apoptosis by regulating the expression of key apoptotic proteins, leading to a variety of antitumor effects. This review identifies the major apoptotic proteins and elaborates the interaction between the apoptotic proteins and various natural anti-cancer products. Conclusion This review provides substantial evidences of apoptosis pathways in cancer cells and the apoptotic proteins modulated by active natural products, which may help to gain a comprehensive understanding for the development of natural drugs for better cancer treatment.
- Subjects :
- 0301 basic medicine
Pharmacology
Biological Products
Programmed cell death
Clinical Biochemistry
Apoptosis pathways
Cancer therapy
Cancer
Apoptosis
Biology
medicine.disease
03 medical and health sciences
030104 developmental biology
Cancer cell apoptosis
Neoplasms
Cancer cell
Cancer research
medicine
Animals
Humans
Apoptosis Regulatory Proteins
Receptor
Signal Transduction
Subjects
Details
- ISSN :
- 13892002
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Current Drug Metabolism
- Accession number :
- edsair.doi.dedup.....e2fc9ddfc3080342df0e6df3d163ae04