Back to Search
Start Over
Hepatic Secretion and Urinary Excretion of Three S35-Labeled Phenothiazines in the Dog
- Source :
- Journal of Pharmaceutical Sciences. 53:1211-1213
- Publication Year :
- 1964
- Publisher :
- Elsevier BV, 1964.
-
Abstract
- The present studies indicate that in the dog chlorpromazine, prochlorperazine, and trifluoperazine are rapidly absorbed from the intestine and that there is a rapid hepatic clearance of the phenothiazines. The biliary and urinary excretions of these compounds are greatly affected by the side chain of the phenothiazine nucleus. The “methylpiperazinylpropyl” side chain (prochlorperazine and trifluoperazine) markedly increases the rate of biliary excretion and reduces the urinary excretion of the parent compounds and/or their metabolites compared with the excretion of chlorpromazine and/or its metabolites (dimethylaminopropyl side chain). Moreover, chlorpromazine and/or its metabolites excreted in bile are reabsorbed from the intestine, resulting in an entero-hepatic recirculation.
- Subjects :
- medicine.medical_specialty
Chlorpromazine
Urinary system
Pharmaceutical Science
Urine
Trifluoperazine
Pharmacology
Intestinal absorption
Prochlorperazine
Excretion
chemistry.chemical_compound
Dogs
Phenothiazines
Phenothiazine
Internal medicine
Sulfur Isotopes
medicine
Bile
Research
Body Fluids
Metabolism
Endocrinology
Intestinal Absorption
chemistry
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 00223549
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmaceutical Sciences
- Accession number :
- edsair.doi.dedup.....e300b226d2328a0f677f05e88d72b745