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Hematopoietic stem cell transplantation for acute myeloid leukemia: A review
- Source :
- Hematology/Oncology and Stem Cell Therapy, Vol 10, Iss 4, Pp 245-251 (2017)
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Increasing numbers of patients are receiving allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML). Scientific and clinical advances in supportive care, donor selection, and conditioning regimens have resulted in lower transplant-related mortality, extension of care to a wider population of patients, and improvements in survival. Recent era has witnessed an explosive information about the molecular pathophysiology of AML. By early identification of patients at a high risk of relapse, it is expected that a majority of eligible patients will receive HCT in first complete remission. Novel conditioning regimens have been explored to improve transplant outcomes in AML. Currently, a stem cell source can be found for virtually all patients who have an indication to receive HCT. This area of investigation will likely continue to be of intense interest in terms of optimizing transplant outcomes. Keywords: Acute myeloid leukemia, Allogeneic hematopoietic cell transplantation, Novel conditioning regimens, Minimal residual disease
- Subjects :
- Oncology
medicine.medical_specialty
medicine.medical_treatment
Population
Hematopoietic stem cell transplantation
lcsh:RC254-282
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Internal medicine
hemic and lymphatic diseases
Medicine
Humans
Intensive care medicine
education
education.field_of_study
business.industry
Donor selection
lcsh:RC633-647.5
Complete remission
Hematopoietic Stem Cell Transplantation
Myeloid leukemia
Hematology
General Medicine
lcsh:Diseases of the blood and blood-forming organs
Allografts
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Minimal residual disease
Transplantation
Survival Rate
Leukemia, Myeloid, Acute
surgical procedures, operative
030220 oncology & carcinogenesis
Stem cell
business
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 16583876
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Hematology/Oncology and Stem Cell Therapy
- Accession number :
- edsair.doi.dedup.....e303d8b9249bfe8be028daec11c82ec8