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Hematopoietic stem cell transplantation for acute myeloid leukemia: A review

Authors :
Adetola A. Kassim
Bipib N. Savani
Source :
Hematology/Oncology and Stem Cell Therapy, Vol 10, Iss 4, Pp 245-251 (2017)
Publication Year :
2017
Publisher :
Elsevier, 2017.

Abstract

Increasing numbers of patients are receiving allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML). Scientific and clinical advances in supportive care, donor selection, and conditioning regimens have resulted in lower transplant-related mortality, extension of care to a wider population of patients, and improvements in survival. Recent era has witnessed an explosive information about the molecular pathophysiology of AML. By early identification of patients at a high risk of relapse, it is expected that a majority of eligible patients will receive HCT in first complete remission. Novel conditioning regimens have been explored to improve transplant outcomes in AML. Currently, a stem cell source can be found for virtually all patients who have an indication to receive HCT. This area of investigation will likely continue to be of intense interest in terms of optimizing transplant outcomes. Keywords: Acute myeloid leukemia, Allogeneic hematopoietic cell transplantation, Novel conditioning regimens, Minimal residual disease

Details

Language :
English
ISSN :
16583876
Volume :
10
Issue :
4
Database :
OpenAIRE
Journal :
Hematology/Oncology and Stem Cell Therapy
Accession number :
edsair.doi.dedup.....e303d8b9249bfe8be028daec11c82ec8