Back to Search
Start Over
The Therapeutic Potential of PTEN Modulation: Targeting Strategies from Gene to Protein
- Source :
- McLoughlin, N M, Mueller, C & Grossmann, T N 2018, ' The Therapeutic Potential of PTEN Modulation : Targeting Strategies from Gene to Protein ', Cell Chemical Biology, vol. 25, no. 1, pp. 19-29 . https://doi.org/10.1016/j.chembiol.2017.10.009
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Two decades have passed since the discovery of the tumor suppressor, PTEN. A multitude of biological functions have since been revealed, suggesting potential therapeutic applications for both PTEN activation (e.g., cancer) and inhibition (e.g., neuroregeneration). Nevertheless, PTEN's therapeutic suitability has been called into question due to its "risky" profile as a tumor suppressor. To evaluate PTEN function and its various roles in disease a number of molecules have so far been developed. However, intrinsic problems associated with phosphatase inhibition and PTEN's complex regulation via post-translational modifications hinder straightforward access to selective modulators. For this reason, central questions associated with PTEN targeting remain unanswered. In this perspective, we summarize current PTEN-targeting strategies and discuss potential approaches to modulate its functional dose, considering all stages of PTEN biogenesis from direct protein modulation to the targeting of relevant miRNAs as well as the PTEN gene and mRNA.
- Subjects :
- 0301 basic medicine
Clinical Biochemistry
Biochemistry
phosphatase
law.invention
Protein–protein interaction
protein-protein interaction
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Genome editing
law
Drug Discovery
microRNA
cancer
Humans
PTEN
miRNA maturation
Enzyme Inhibitors
Molecular Biology
Pharmacology
biology
gene editing
PTEN Phosphohydrolase
Neurodegenerative Diseases
Neuroregeneration
new modalities
Human Health and Life Sciences
030104 developmental biology
030220 oncology & carcinogenesis
anti-sense
Cancer research
biology.protein
Molecular Medicine
Suppressor
miR-21
anti-gene
Function (biology)
Biogenesis
Subjects
Details
- ISSN :
- 24519456
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Cell Chemical Biology
- Accession number :
- edsair.doi.dedup.....e30f30bb75502326b429b623c3a821e2
- Full Text :
- https://doi.org/10.1016/j.chembiol.2017.10.009