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Immunosuppression et cellules souches mésenchymateuses Mieux comprendre une propriété thérapeutique majeure
- Source :
- médecine/sciences, médecine/sciences, 2011, 27 (3), pp.269-274. ⟨10.1051/medsci/2011273269⟩, médecine/sciences, EDP Sciences, 2011, 27 (3), pp.269-274. ⟨10.1051/medsci/2011273269⟩
- Publication Year :
- 2011
- Publisher :
- HAL CCSD, 2011.
-
Abstract
- International audience; Since their efficiency to treat graft versus host disease has been proven, mesenchymal stem cells (MSC) represent a promising cell therapy approach for the treatment of immune disorders. In this context, much attention has focused on their mechanisms of action, in particular once the fact that their immune properties are also crucial for their efficiency in regenerative medicine was demonstrated. By their production of various and redundant soluble factors, MSC exert powerful anti-inflammatory and immunosuppressive effects targeting the main immune cell subsets. These immunoregulatory properties are essentially inducible by inflammatory mediators. In addition, it is now clear that allogeneic MSC are not immunoprivileged in immunocompetent recipient in agreement with their low persistence in vivo. They should thus display an early "touch-and-go" effect involving both direct interactions with recruited immune effectors and further amplification of this immunosuppression process through activation or conditioning of other regulatory immune cells. A better understanding of immunological properties of MSC will clearly improve their use in clinical settings.; Les cellules souches mésenchymateuses (CSM) possèdent des propriétés immunosuppressives très vastes liées à la production de facteurs solubles inductibles qui inhibent l'activation des principaux effecteurs de l'immunité. L'intérêt de ces propriétés a été confirmé dans des essais cliniques spectaculaires chez des patients atteints de la maladie du greffon contre l'hôte, une complication fréquente et grave des allogreffes de cellules souches hématopoïétiques. Depuis, les applications de ce potentiel anti-inflammatoire et immunosuppresseur des CSM ont été étendues à la médecine régénératrice puisque les capacités de réparation des CSM semblent étroitement liées à leurs propriétés immunologiques, démontrant tout l'intérêt d'une compréhension fine des interactions entre les CSM et les cellules immunitaires.
- Subjects :
- MESH: Forecasting
0303 health sciences
MESH: Humans
MESH: Immune Tolerance
[SDV.CAN]Life Sciences [q-bio]/Cancer
General Medicine
Biology
Molecular biology
MESH: Adaptation, Physiological
General Biochemistry, Genetics and Molecular Biology
3. Good health
03 medical and health sciences
0302 clinical medicine
MESH: Mesenchymal Stem Cells
030220 oncology & carcinogenesis
MESH: Animals
MESH: Mesenchymal Stem Cell Transplantation
030304 developmental biology
Subjects
Details
- Language :
- French
- ISSN :
- 07670974 and 19585381
- Database :
- OpenAIRE
- Journal :
- médecine/sciences, médecine/sciences, 2011, 27 (3), pp.269-274. ⟨10.1051/medsci/2011273269⟩, médecine/sciences, EDP Sciences, 2011, 27 (3), pp.269-274. ⟨10.1051/medsci/2011273269⟩
- Accession number :
- edsair.doi.dedup.....e35e6f412185e848ae1e502bb1eb8095