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SNHG7: A novel vital oncogenic lncRNA in human cancers
- Source :
- Biomedicine & Pharmacotherapy, Vol 124, Iss, Pp 109921-(2020)
- Publication Year :
- 2019
-
Abstract
- Long noncoding RNAs (lncRNAs) are a group of RNAs that lack protein-coding ability, with lengths greater than 200 nucleotides. Increasing evidence has indicated that they mediate multiple physiological and pathological processes by regulating gene expression at the epigenetic, transcriptional, post-transcriptional, and translational levels. The deregulation of lncRNAs was demonstrated to have tumor suppressive or oncogenic effects, and thus, these molecules play vital regulatory roles in tumor initiation and progression. Small nucleolar RNA hostgene 7 (SNHG7) is a lncRNA located on chromosome 9q34.3. Different studies have explored the potential role of SNHG7 in the development and progression of multiple human malignancies such as bladder, breast, colorectal, esophageal, gastric, and prostate cancer, as well as osteosarcoma, among others, and high expression predicts poor prognosis and poor survival for such patients. Moreover, this molecule can promote proliferation and metastasis, while inhibiting apoptosis in cancer cells. The present review highlights the latest insights into the expression, functional roles, and molecular mechanisms of SNHG7 in different human malignancies.
- Subjects :
- 0301 basic medicine
Carcinogenesis
Apoptosis
Tumor initiation
RM1-950
Biology
Metastasis
Molecular mechanism
SNHG7
Functional role
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Neoplasms
Gene expression
medicine
Humans
Epigenetics
Small nucleolar RNA
Cell Proliferation
Pharmacology
Human cancers
General Medicine
medicine.disease
Prognosis
Long non-coding RNA
Gene Expression Regulation, Neoplastic
Survival Rate
030104 developmental biology
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Disease Progression
RNA, Long Noncoding
Therapeutics. Pharmacology
Long noncoding RNA
Subjects
Details
- ISSN :
- 19506007
- Volume :
- 124
- Database :
- OpenAIRE
- Journal :
- Biomedicinepharmacotherapy = Biomedecinepharmacotherapie
- Accession number :
- edsair.doi.dedup.....e36d15418a36bef8e450ef58c8d3f53c