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Metastatic Inflammatory Myofibroblastic Tumor of the Spleen: A Case Report and Review of the Literature
Metastatic Inflammatory Myofibroblastic Tumor of the Spleen: A Case Report and Review of the Literature
- Source :
- Case Reports in Surgery, Case Reports in Surgery, Vol 2016 (2016)
- Publication Year :
- 2016
-
Abstract
- Introduction.Inflammatory myofibroblastic tumors (IMT) of the spleen are rare neoplasms and only little is known about the origin and behavior of these tumors. Here we report the case of a 37-year-old woman with an atypical spindle cell neoplasm showing features strongly suggesting an IMT of the spleen with hepatic metastasis.Methods.A 37-year-old patient had been complaining about pain in the left upper abdomen for the last two months. A CT scan revealed a tumor mass in her spleen and liver. After complete staging, a splenectomy and atypical liver resection of segments VII and VIII were performed. Literature was screened for similar cases and existing further literature.Results.A R0 resection was achieved. Histological analysis showed a multinodular infiltration of the spleen by an atypical mesenchymal neoplasia. Immunohistochemically there was an expression of histiocytic markers (CD4, CD68) as well as smooth muscle cell markers (SMA, H-Caldesmon) in the tumor cells. A diagnosis of an atypical spindle cell neoplasm showing features most suggestive of an IMT was rendered.Conclusion.Synchronous hepatic metastasis of an IMT of the spleen is a rarity. Therefore no experience in the treatment of these tumors exists. Fibroblastic reticular cell tumor is a differential diagnosis, but differentiation of these two entities is difficult.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Fibroblastic Reticular Cell Tumor
business.industry
CD68
medicine.medical_treatment
Splenectomy
Mesenchymal stem cell
lcsh:Surgery
Spleen
Case Report
lcsh:RD1-811
Stem cell marker
Surgery
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
030220 oncology & carcinogenesis
medicine
Pharmacology (medical)
Differential diagnosis
business
Histiocyte
Subjects
Details
- ISSN :
- 20906900
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- Case reports in surgery
- Accession number :
- edsair.doi.dedup.....e388407419a29c7a2e7c50cf984cd55d