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Three new lanostane triterpenoids and two new amides from Alternaria sp. with NLRP3 inflammasome inhibitory activity
- Source :
- Natural Product Research. :1-10
- Publication Year :
- 2023
- Publisher :
- Informa UK Limited, 2023.
-
Abstract
- Three new lanostane triterpenoids (1-3) along with two new amides fatty compounds (4-5) were isolated from the ethyl acetate extract of a culture of the endophytic fungus Alternaria sp. gx-2. Their structures were identified by 1D and 2D NMR spectral data and HRESIMS. Compounds 1-12 were evaluated for their anti-inflammatory and tyrosinase inhibition activities. The isolated compounds did not show inhibitory activities at a concentration of 100 μM against tyrosinase, while under the concentration of 10 μM, the release of lactate dehydrogenase (LDH) inhibition rate of compound 1 was 54.45%, indicating that compound 1 had moderate anti-inflammatory activity on the activation of NLRP3 inflammasome.
- Subjects :
- Organic Chemistry
Plant Science
Biochemistry
Analytical Chemistry
Subjects
Details
- ISSN :
- 14786427 and 14786419
- Database :
- OpenAIRE
- Journal :
- Natural Product Research
- Accession number :
- edsair.doi.dedup.....e38940206eee5e2880dae877550fe0b9