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Test-retest reliability of prefrontal transcranial Direct Current Stimulation (tDCS) effects on functional MRI connectivity in healthy subjects
- Source :
- NeuroImage. 155
- Publication Year :
- 2017
-
Abstract
- Transcranial Direct Current Stimulation (tDCS) of the prefrontal cortex (PFC) can be used for probing functional brain connectivity and meets general interest as novel therapeutic intervention in psychiatric and neurological disorders. Along with a more extensive use, it is important to understand the interplay between neural systems and stimulation protocols requiring basic methodological work. Here, we examined the test-retest (TRT) characteristics of tDCS-induced modulations in resting-state functional-connectivity MRI (RS fcMRI). Twenty healthy subjects received 20minutes of either active or sham tDCS of the dorsolateral PFC (2mA, anode over F3 and cathode over F4, international 10-20 system), preceded and ensued by a RS fcMRI (10minutes each). All subject underwent three tDCS sessions with one-week intervals in between. Effects of tDCS on RS fcMRI were determined at an individual as well as at a group level using both ROI-based and independent-component analyses (ICA). To evaluate the TRT reliability of individual active-tDCS and sham effects on RS fcMRI, voxel-wise intra-class correlation coefficients (ICC) of post-tDCS maps between testing sessions were calculated. For both approaches, results revealed low reliability of RS fcMRI after active tDCS (ICC(2,1) = -0.09 - 0.16). Reliability of RS fcMRI (baselines only) was low to moderate for ROI-derived (ICC(2,1) = 0.13 - 0.50) and low for ICA-derived connectivity (ICC(2,1) = 0.19 - 0.34). Thus, for ROI-based analyses, the distribution of voxel-wise ICC was shifted to lower TRT reliability after active, but not after sham tDCS, for which the distribution was similar to baseline. The intra-individual variation observed here resembles variability of tDCS effects in motor regions and may be one reason why in this study robust tDCS effects at a group level were missing. The data can be used for appropriately designing large scale studies investigating methodological issues such as sources of variability and localisation of tDCS effects.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Cognitive Neuroscience
medicine.medical_treatment
Prefrontal Cortex
Pilot Projects
Transcranial Direct Current Stimulation
050105 experimental psychology
Correlation
03 medical and health sciences
Functional brain
Young Adult
0302 clinical medicine
Physical medicine and rehabilitation
Neuroimaging
Double-Blind Method
Image Interpretation, Computer-Assisted
Neural Pathways
medicine
Humans
0501 psychology and cognitive sciences
Prefrontal cortex
Reliability (statistics)
medicine.diagnostic_test
Transcranial direct-current stimulation
05 social sciences
Healthy subjects
Reproducibility of Results
Magnetic resonance imaging
Magnetic Resonance Imaging
Neurology
Female
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10959572
- Volume :
- 155
- Database :
- OpenAIRE
- Journal :
- NeuroImage
- Accession number :
- edsair.doi.dedup.....e3928353fa49bbf331d57ed6cf669051