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Health-Related Quality of Life (HRQoL) in Sarcoidosis: Diagnosis, Management, and Health Outcomes
- Source :
- Diagnostics, Diagnostics, Vol 11, Iss 1089, p 1089 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Health-related quality of life (HRQoL), though rarely considered as a primary endpoint in clinical trials, may be the single outcome reflective of patient priorities when living with a health condition. HRQoL is a multi-dimensional concept that reflects the degree to which a health condition interferes with participation in and fulfillment of important life areas. HRQoL is intended to capture the composite degree of physical, physiologic, psychological, and social impairment resulting from symptom burden, patient-perceived disease severity, and treatment side effects. Diminished HRQoL expectedly correlates to worsening disability and death; but interventions addressing HRQoL are linked to increased survival. Sarcoidosis, being a multi-organ system disease, is associated with a diffuse array of manifestations resulting in multiple symptoms, complications, and medication-related side effects that are linked to reduced HRQoL. Diminished HRQoL in sarcoidosis is related to decreased physical function, pain, significant loss of income, absence from work, and strain on personal relationships. Symptom distress can result clearly from a sarcoidosis manifestation (e.g., ocular pain, breathlessness, cough) but may also be non-specific, such as pain or fatigue. More complex, a single non-specific symptom, e.g., fatigue may be directly sarcoidosis-derived (e.g., inflammatory state, neurologic, hormonal, cardiopulmonary), medication-related (e.g., anemia, sleeplessness, weight gain, sub-clinical infection), or an indirect complication (e.g., sleep apnea, physical deconditioning, depression). Identifying and distinguishing underlying causes of impaired HRQoL provides opportunity for treatment strategies that can greatly impact a patient’s function, well-being, and disease outcomes. Herein, we present a reference manual that describes the current state of knowledge in sarcoidosis-related HRQoL and distinguish between diverse causes of symptom distress and other influences on sarcoidosis-related HRQoL. We provide tools to assess, investigate, and diagnose compromised HRQoL and its influencers. Strategies to address modifiable HRQoL factors through palliation of symptoms and methods to improve the sarcoidosis health profile are outlined; as well as a proposed research agenda in sarcoidosis-related HRQoL.
- Subjects :
- medicine.medical_specialty
Medicine (General)
symptom burden
Palliative care
mindfulness
FATIGUE ASSESSMENT SCALE
Clinical Biochemistry
shared decision making
Psychological intervention
physical activity
Disease
Review
INTERSTITIAL LUNG-DISEASE
PALLIATIVE CARE
03 medical and health sciences
symptom distress
0302 clinical medicine
R5-920
Quality of life
EVERYDAY COGNITIVE FAILURE
medicine
Clinical endpoint
patient-centeredness
030212 general & internal medicine
sarcoidosis
Intensive care medicine
Depression (differential diagnoses)
ALL-CAUSE MORTALITY
IMPORTANT DIFFERENCE
exercise
business.industry
SYSTEMIC-SCLEROSIS
Sleep apnea
PATIENT PERSPECTIVES
SMALL FIBER NEUROPATHY
medicine.disease
humanities
Clinical trial
030228 respiratory system
quality of life
IDIOPATHIC PULMONARY-FIBROSIS
patient centered care
business
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 11
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....e396f9260eff94ae3b300d9a97709582