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Squamous Cell Carcinoma of the Oral Tongue in Young Non-Smokers Is Genomically Similar to Tumors in Older Smokers
- Source :
- Clinical Cancer Research. 20:3842-3848
- Publication Year :
- 2014
- Publisher :
- American Association for Cancer Research (AACR), 2014.
-
Abstract
- Purpose: Epidemiologic studies have identified an increasing incidence of squamous cell carcinoma of the oral tongue (SCCOT) in younger patients. Experimental Design: DNA isolated from tongue tumors of young (45 years) patients at was subjected to whole-exome sequencing and copy-number analysis. These data were compared with data from similar patients in the TCGA (The Cancer Genome Atlas) project. Results: In this study, we found that gene-specific mutation and copy-number alteration frequencies were similar between young and old patients with SCCOT in two independent cohorts. Likewise, the types of base changes observed in the young cohort were similar to those in the old cohort even though they differed in smoking history. TCGA data also demonstrate that the genomic effects of smoking are tumor site–specific, and we find that smoking has only a minor impact on the types of mutations observed in SCCOT. Conclusions: Overall, tumors from young patients with SCCOT appear genomically similar to those of older patients with SCCOT, and the cause for the increasing incidence of young SCCOT remains unknown. These data indicate that the functional impact of smoking on carcinogenesis in SCCOT is still poorly understood. Clin Cancer Res; 20(14); 3842–8. ©2014 AACR.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Pathology
DNA Copy Number Variations
DNA Mutational Analysis
Biology
medicine.disease_cause
Article
Older patients
Tongue
Internal medicine
Cancer genome
medicine
Carcinoma
Humans
Basal cell
Tongue Neoplasm
Smoking
Age Factors
Middle Aged
Prognosis
medicine.disease
Tongue Neoplasms
medicine.anatomical_structure
Mutation
Cohort
Carcinoma, Squamous Cell
Female
Carcinogenesis
Subjects
Details
- ISSN :
- 15573265 and 10780432
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Clinical Cancer Research
- Accession number :
- edsair.doi.dedup.....e3a1e66e8a6cae9713551b54bac05ce9