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Reduced expression of NR4A1 activates glycolytic pathway in acute promyelocytic leukemia cells
- Source :
- Leukemialymphoma. 59(6)
- Publication Year :
- 2017
-
Abstract
- Acute myeloid leukemia (AML) cells exhibit altered glucose metabolism that is associated with poor prognosis and chemotherapy resistance [1]. Nuclear receptor subfamily four group A member 1 (NR4A1...
- Subjects :
- 0301 basic medicine
Acute promyelocytic leukemia
Cancer Research
Bone Marrow Cells
03 medical and health sciences
Promyelocytic leukemia protein
0302 clinical medicine
Leukemia, Promyelocytic, Acute
hemic and lymphatic diseases
medicine
Nuclear Receptor Subfamily 4, Group A, Member 1
Gene silencing
Humans
Glycolysis
Gene Silencing
Regulation of gene expression
biology
Chemistry
Gene Expression Regulation, Leukemic
Myeloid leukemia
Hematology
medicine.disease
Leukemia
030104 developmental biology
Glucose
Oncology
Nuclear receptor
030220 oncology & carcinogenesis
biology.protein
Cancer research
Biomarkers
Metabolic Networks and Pathways
Subjects
Details
- ISSN :
- 10292403
- Volume :
- 59
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Leukemialymphoma
- Accession number :
- edsair.doi.dedup.....e3a22a455a2fe367a0706b68965c313c