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IgA Levels Are Associated with Coronary Artery Lesions in Kawasaki Disease
- Source :
- Korean Circulation Journal
- Publication Year :
- 2021
- Publisher :
- The Korean Society of Cardiology, 2021.
-
Abstract
- Background and Objectives Kawasaki disease (KD) is an acute systemic vasculitis that affects the coronary arteries. Abnormal immune reactions are thought to contribute to disease pathogenesis. The effect of immunoglobulin (Ig) isotype (IgG, IgA, IgM, and IgE) on inflammatory data and clinical outcomes of patients with KD was examined. Methods Ig levels in 241 patients with KD were measured during the acute, subacute, convalescent, and normal phases of the disease. Results Compared with reference Ig values, IgG, IgA, and IgM levels were significantly higher in the subacute phase, while IgE levels were elevated in 73.9% (178/241) of patients with KD in all clinical phases. However, high IgE levels were not associated with clinical outcomes, including intravenous immunoglobulin unresponsiveness and coronary artery lesions (CALs). Significantly more CALs were observed in the high IgA group than in the normal IgA group (44.7% vs. 20.8%, respectively; p
- Subjects :
- medicine.medical_specialty
Coronary aneurysms
030204 cardiovascular system & hematology
Immunoglobulin E
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Internal Medicine
medicine
030212 general & internal medicine
Original Research
Coronary artery aneurysm
biology
business.industry
Odds ratio
medicine.disease
Isotype
Coronary arteries
medicine.anatomical_structure
biology.protein
Kawasaki disease
Antibody
Mucocutaneous lymph node syndrome
Cardiology and Cardiovascular Medicine
business
IgA
Systemic vasculitis
Subjects
Details
- ISSN :
- 17385555 and 17385520
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Korean Circulation Journal
- Accession number :
- edsair.doi.dedup.....e3b44cca01954df01ae817f0a1203c91
- Full Text :
- https://doi.org/10.4070/kcj.2020.0345