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Evaluating genetic risk for prostate cancer among Japanese and Latinos
- Source :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(11)
- Publication Year :
- 2012
-
Abstract
- Background: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos. Methods: Our first-stage GWAS of prostate cancer included Japanese (cases/controls = 1,033/1,042) and Latino (cases/controls = 1,043/1,057) from the Multiethnic Cohort (MEC). Significant associations from stage I (P < 1.0 × 10−4) were examined in silico in GWAS of prostate cancer (stage II) in Japanese (cases/controls = 1,583/3,386) and Europeans (cases/controls = 1,854/1,894). Results: No novel stage I single-nucleotide polymorphism (SNP) outside of known risk regions reached genome-wide significance. For Japanese, in stage I, the most notable putative novel association was seen with 10 SNPs (P ≤ 8.0 × 10−6) at chromosome 2q33; however, this was not replicated in stage II. For Latinos, the most significant association was observed with rs17023900 at the known 3p12 risk locus (stage I: OR = 1.45; P = 7.01 × 10−5 and stage II: OR = 1.58; P = 3.05 × 10−7). The majority of the established risk variants for prostate cancer, 79% and 88%, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively. The cumulative effects of these variants significantly influence prostate cancer risk (OR per allele = 1.10; P = 2.71 × 10−25 and OR = 1.07; P = 1.02 × 10−16 for Japanese and Latinos, respectively). Conclusion and Impact: Our GWAS of prostate cancer did not identify novel genome-wide significant variants. However, our findings show that established risk variants for prostate cancer significantly contribute to risk among Japanese and Latinos. Cancer Epidemiol Biomarkers Prev; 21(11); 2048–58. ©2012 AACR.
- Subjects :
- Oncology
Male
Risk
medicine.medical_specialty
Genotype
Epidemiology
Single-nucleotide polymorphism
Genome-wide association study
Polymorphism, Single Nucleotide
California
Hawaii
Article
Cohort Studies
Prostate cancer
Asian People
Japan
Internal medicine
medicine
SNP
Humans
Genetic Predisposition to Disease
Allele
Genetic association
Neoplasm Staging
Genetics
Models, Statistical
business.industry
Prostatic Neoplasms
Hispanic or Latino
medicine.disease
business
Cohort study
Genome-Wide Association Study
SEER Program
Subjects
Details
- ISSN :
- 15387755
- Volume :
- 21
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Accession number :
- edsair.doi.dedup.....e3ba618b5e9ee92f35b54b42b94e86b3