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Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: A randomized, controlled trial
- Source :
- Brain, behavior, and immunity, Brain, Behavior, and Immunity, Vol. 94, no. May, p. 289-298 (2021)
- Publication Year :
- 2020
-
Abstract
- Background and aims Metabolic and behavioural diseases, which are often related to obesity, have been associated to alterations of the gut microbiota considered as an interesting therapeutic target. We have analyzed in a cohort of obese patients treated with prebiotic inulin versus placebo the potential link between gut microbiota changes occurring upon intervention and their effect on psychological parameters (mood and cognition). Methods A randomized, single-blinded, multicentric, placebo-controlled trial was conducted in 106 obese patients assigned to two groups: prebiotic versus placebo, who received respectively 16 g/d of native inulin or maltodextrin combined with dietary advice to consume inulin-rich or -poor vegetables for 3 months as well as to restrict caloric intake. Anthropometric measurements, food intake, psychological questionnaires, serum measures, and fecal microbiome sequencing were performed before and after the intervention. Results Inulin supplementation in obese subjects had moderate beneficial effect on emotional competence and cognitive flexibility. However, an exploratory analysis revealed that some patients exhibiting specific microbial signature -elevated Coprococcus levels at baseline- were more prone to benefit from prebiotic supplementation in terms of mood. Positive responders toward inulin intervention in term of mood also displayed worse metabolic and inflammatory profiles at baseline (increased levels of IL-8, insulin resistance and adiposity). Conclusion This study shows that inulin intake can be helpful to improve mood in obese subjects exhibiting a specific microbial profile. The present work highlights some microbial, metabolic and inflammatory features (IL-8, insulin resistance) which can predict or mediate the beneficial effects of inulin on behaviour in obesity. Food4gut, clinicaltrial.gov: NCT03852069, https://clinicaltrials.gov/ct2/show/NCT03852069 .
- Subjects :
- cognition
0301 basic medicine
obesity
mood
medicine.medical_treatment
Immunology
Inulin
Physiology
Gut microbiota
Gut flora
Placebo
law.invention
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
Feces
0302 clinical medicine
Insulin resistance
Randomized controlled trial
law
Medicine
Humans
Obesity
biology
Endocrine and Autonomic Systems
business.industry
Prebiotic
clinical trial
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
030104 developmental biology
Mood
Prebiotics
chemistry
prebiotic
business
Biologie
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10902139
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Brain, behavior, and immunity
- Accession number :
- edsair.doi.dedup.....e3bb98cb98d047e0d1e2db32f3cb73cc