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Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19
- Source :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
- Publication Year :
- 2020
-
Abstract
- In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infections, pathogenesis and progression have not been clearly elucidated yet, thus forcing the development of many complementary approaches to identify candidate cellular pathways involved in disease progression. Host lipids play a critical role in the virus life, being the double-membrane vesicles a key factor in coronavirus replication. Moreover, lipid biogenesis pathways affect receptor-mediated virus entry at the endosomal cell surface and modulate virus propagation. In this study, targeted lipidomic analysis coupled with proinflammatory cytokines and alarmins measurement were carried out in serum of COVID-19 patients characterized by different severity degree. Serum IL-26, a cytokine involved in IL-17 pathway, TSLP and adiponectin were measured and correlated to lipid COVID-19 patient profiles. These results could be important for the classification of the COVID-19 disease and the identification of therapeutic targets.
- Subjects :
- Male
Science
medicine.medical_treatment
Diseases
Disease
medicine.disease_cause
Severity of Illness Index
Biochemistry
Virus
Article
Proinflammatory cytokine
Pathogenesis
Intensive care
medicine
Alarmins
Humans
Least-Squares Analysis
Cytokine
Coronavirus
Least-Squares Analysi
Multidisciplinary
Molecular medicine
business.industry
SARS-CoV-2
COVID-19
Discriminant Analysis
Lipid metabolism
Lipid
Middle Aged
Lipid Metabolism
Lipids
Alarmin
Immunology
Medicine
Cytokines
Female
Discriminant Analysi
business
Human
Biotechnology
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....e3c86f87d239607227548efa816a6383