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Diminished expression of S100A2, a putative tumour suppressor, is an independent predictive factor of neck node relapse in laryngeal squamous cell carcinoma
- Source :
- Scopus-Elsevier, Europe PubMed Central
- Publication Year :
- 2009
-
Abstract
- In primary squamous cell carcinoma of the larynx (LSCC), Ca(2+) binding S100A2 protein underexpression was already found to be associated with poor tumour differentiation and shorter overall survival. In the present work, the role of S100A2 protein expression in the prediction of regional metastasis-free survival (MFS) was investigated to guide neck management in LSCC.Specimens of LSCC from 62 consecutive untreated patients were examined for S100A2 content by immunocytochemistry; the patients were followed up for a median of 44 months (range 2-90 months) after initial surgical resection. MFS was calculated from the date of first surgery to that of regional neck node recurrence.S100A2 was detected in 18 of 19 (95%) low-grade tumours and in 22 of 43 (51%) high-grade tumours. The 5-year regional MFS was 81% for patients with S100A2-positive tumours and 55% for patients with S100A2-negative tumours. By multivariate analysis, the S100A2 status appeared to be a significant independent predictive factor for MFS (p = .02).Our results suggest that the assessment of S100A2 status at diagnosis may identify a subset of LSCC patients highly susceptible to neck node metastases and may thus help define therapy accordingly.
- Subjects :
- Settore BIO/16 - ANATOMIA UMANA
Chemotactic Factors
S100 Proteins
Laryngectomy
Radiotherapy Dosage
610 Medicine & health
Combined Modality Therapy
Immunohistochemistry
2746 Surgery
2733 Otorhinolaryngology
Predictive Value of Tests
Recurrence
10036 Medical Clinic
Carcinoma, Squamous Cell
Humans
Genetic Predisposition to Disease
Lymph Nodes
S100A2
CELL
Neoplasm Recurrence, Local
Laryngeal Neoplasms
Neck
Follow-Up Studies
Neoplasm Staging
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Europe PubMed Central
- Accession number :
- edsair.doi.dedup.....e3cd1f9a4717ec8c154be2ca61697329