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An Azo Coupling Strategy for Protein 3-Nitrotyrosine Derivatization

Authors :
Baoxin Zhang
Pengcheng Zhou
Jianguo Fang
Feifei Bai
Honghong Da
Guodong Hu
Huiyi Jia
Yuxin Liu
Source :
Chemistry (Weinheim an der Bergstrasse, Germany). 25(48)
Publication Year :
2019

Abstract

Herein, a strategy for the selective derivatization of 3-nitrotyrosine-containing proteins using the classic azo coupling reaction as the key step is described. This novel approach featured multiple advantages and was successfully applied to detect picomole levels of protein tyrosine nitration in biological samples.

Details

ISSN :
15213765
Volume :
25
Issue :
48
Database :
OpenAIRE
Journal :
Chemistry (Weinheim an der Bergstrasse, Germany)
Accession number :
edsair.doi.dedup.....e3dc1d41c7b4920b9da73b1e9d6591b2