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Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study
- Source :
- The Journal of dermatological treatment. 27(1)
- Publication Year :
- 2015
-
Abstract
- Vitamin D3 ointment and corticosteroid ointment are both used for the treatment of palmoplantar pustulosis (PPP). However, to date there is no systematic study of the efficacy of combination therapy for the treatment of PPP.We compared the efficacy of a topical combination therapy with vitamin D3 and a topical corticosteroid with that of topical corticosteroid alone in the treatment of PPP.We evaluated left-right comparison study of the efficacy of a combination therapy consisting of maxacalcitol ointment and betamethasone butyrate propionate ointment (BBP), and monotherapy with BBP alone in 27 patients with PPP for 8 weeks.The improvement in the symptom (erythema, pustules/vesicles, hyperkeratosis/scales) scores was high for the combination therapy. In particular, the improvement rate for pustules/vesicles at week 8 after the combination therapy was significantly higher than for the monotherapy (p 0.05).This combination regimen demonstrated that not only topical corticosteroids, but also topical vitamin D3 ointment, is useful for the treatment of PPP.
- Subjects :
- Vitamin
Adult
Male
medicine.medical_specialty
Palmoplantar pustulosis
Erythema
Combination therapy
medicine.drug_class
Administration, Topical
Hyperkeratosis
Dermatology
Ointments
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Calcitriol
Psoriasis
medicine
Humans
Prospective Studies
Glucocorticoids
Aged
030203 arthritis & rheumatology
Skin Diseases, Vesiculobullous
business.industry
Middle Aged
medicine.disease
Regimen
Treatment Outcome
chemistry
Corticosteroid
Drug Therapy, Combination
Female
Dermatologic Agents
medicine.symptom
business
Subjects
Details
- ISSN :
- 14711753
- Volume :
- 27
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of dermatological treatment
- Accession number :
- edsair.doi.dedup.....e3de8d675414328976c8405e23134bec