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Relation of homocysteine to early nephropathy in patients with Type 2 diabetes
- Source :
- Clinical Nephrology. 77:305-310
- Publication Year :
- 2012
- Publisher :
- Dustri-Verlgag Dr. Karl Feistle, 2012.
-
Abstract
- AIM To explore the relationship between plasma total homocysteine concentration and diabetic nephropathy in patients with Type 2 diabetes. METHODS Chinese patients with Type 2 diabetes (n = 183) were enrolled in a cross-sectional hospital based study. Early diabetic nephropathy status was documented by presence of microalbuminuria. Plasma total homocysteine concentration was measured using fluorescence polarization immunoassay. Traditional risk factors for diabetic nephropathy were obtained from fasting blood samples and interviewer- questionnaire. RESULTS Plasma total homocysteine levels were higher in subjects with early diabetic nephropathy than without (13.3 ± 2.9) μmol/l vs. (8.5 ± 1.4) μmol/l, p < 0.01). The association of homocysteine with the diabetic nephropathy was independent of major traditional risk factors for diabetic nephropathy (duration of diabetes, HbA1c, and blood pressure) and determinants of higher homocysteine concentration (age, gender, serum folate and vitamin B12, serum cystatin and creatinine levels, and Biguanide use) (OR: 1.37 (0.89 - 2.24), p < 0.05). Furthermore, per increase of 4.0 μmol/l plasma homocysteine was related to nephropathy, after controlling for per unit increase of other factors (OR: 1.15 (0.94 - 1.29), p < 0.05). CONCLUSION Plasma total homocysteine concentration was independently associated with occurrence of early diabetic nephropathy in Chinese patients. Future prospective studies are warranted to clarify the relationship.
- Subjects :
- Adult
Male
medicine.medical_specialty
Homocysteine
medicine.drug_class
Type 2 diabetes
Sensitivity and Specificity
Gastroenterology
Nephropathy
Diagnosis, Differential
Diabetic nephropathy
chemistry.chemical_compound
Predictive Value of Tests
Risk Factors
Surveys and Questionnaires
Internal medicine
Diabetes mellitus
medicine
Albuminuria
Humans
Diabetic Nephropathies
Aged
Inpatients
Creatinine
business.industry
Biguanide
General Medicine
Middle Aged
medicine.disease
Cross-Sectional Studies
Early Diagnosis
Diabetes Mellitus, Type 2
chemistry
Nephrology
Female
Microalbuminuria
business
Algorithms
Biomarkers
Subjects
Details
- ISSN :
- 03010430
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Clinical Nephrology
- Accession number :
- edsair.doi.dedup.....e3e1c9f116dfef82cd560b73f94e63e1